| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 3676 |
Name | ITGA4 |
Synonym | CD49D|IA4;integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor);ITGA4;integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) |
Definition | 269C wild type|CD49 antigen-like family member D|VLA-4 subunit alpha|antigen CD49D, alpha-4 subunit of VLA-4 receptor|integrin alpha 4|integrin alpha-4|integrin alpha-4 subunit|integrin alpha-IV|very late activation protein 4 receptor, alpha 4 subunit |
Position | 2q31.3 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | Hemostasis;Reactome;REACT:604 |
Pathway | Arrhythmogenic right ventricular cardiomyopathy (ARVC);KEGG PATHWAY;hsa05412 |
Pathway | a4b1 and a4b7 Integrin signaling;PID Curated;200092 |
Pathway | ECM-receptor interaction;KEGG PATHWAY;hsa04512 |
Pathway | Paxillin-dependent events mediated by a4b1;PID Curated;200117 |
Pathway | Regulation of actin cytoskeleton;KEGG PATHWAY;hsa04810 |
Pathway | Focal adhesion;KEGG PATHWAY;hsa04510 |
Pathway | Cell surface interactions at the vascular wall;PID Reactome;500305 |
Pathway | Signaling in Immune system;Reactome;REACT:6900 |
Pathway | Integrin signalling pathway;PANTHER;P00034 |
Pathway | Hematopoietic cell lineage;KEGG PATHWAY;hsa04640 |
Pathway | Cell adhesion molecules (CAMs);KEGG PATHWAY;hsa04514 |
Pathway | Dilated cardiomyopathy;KEGG PATHWAY;hsa05414 |
Pathway | Integrin cell surface interactions;PID Reactome;500004 |
Pathway | Hypertrophic cardiomyopathy (HCM);KEGG PATHWAY;hsa05410 |
Pathway | Leukocyte transendothelial migration;KEGG PATHWAY;hsa04670 |
Pathway | Leishmaniasis;KEGG PATHWAY;hsa05140 |
Pathway | Paxillin-independent events mediated by a4b1 and a4b7;PID Curated;200178 |
Pathway | Integrin cell surface interactions;Reactome;REACT:13552 |
Pathway | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;PID Reactome;500477 |
Pathway | Intestinal immune network for IgA production;KEGG PATHWAY;hsa04672 |
Disease | Osteosarcoma;FunDO |
Disease | Virus disease;FunDO |
Disease | Overnutrition;FunDO |
Disease | Lung disease;FunDO |
Disease | smoking cessation;GAD |
Disease | CHEMDEPENDENCY;GAD |
Disease | Leukemia;FunDO |
Disease | Celiac Disease;GAD |
Disease | Asthma;FunDO |
Disease | Rheumatoid arthritis;FunDO |
Disease | Esophagus cancer;FunDO |
Disease | Thalassemia;FunDO |
Disease | Melanoma;FunDO |
Disease | Systemic infection;FunDO |
Disease | Purpura, Thrombocytopenic, Idiopathic;FunDO |
Disease | Sickle cell disease;FunDO |
Disease | Celiac disease;NHGRI |
Disease | Demyelinating disease;FunDO |
Disease | IMMUNE;GAD |
External Links | |
Links to Entrez Gene | 3676 |
Links to all GeneRIF Items | 3676 |
Links to iHOP | 3676 |
Sequence Information | |
Nucleotide Sequence | >3676 : length: 6082 ATAACGTCTTTGTCACTAAAATGTTCCCCAGGGGCCTTCGGCGAGTCTTTTTGTTTGGTT TTTTGTTTTTAATCTGTGGCTCTTGATAATTTATCTAGTGGTTGCCTACACCTGAAAAAC AAGACACAGTGTTTAACTATCAACGAAAGAACTGGACGGCTCCCCGCCGCAGTCCCACTC CCCGAGTTTGTGGCTGGCATTTGGGCCACGCCGGGCTGGGCGGTCACAGCGAGGGGCGCG CAGTTTGGGGTCACACAGCTCCGCTTCTAGGCCCCAACCACCGTTAAAAGGGGAAGCCCG TGCCCCATCAGGTCCGCTCTTGCTGAGCCCAGAGCCATCCCGCGCTCTGCGGGCTGGGAG GCCCGGGCCAGGACGCGAGTCCTGCGCAGCCGAGGTTCCCCAGCGCCCCCTGCAGCCGCG CGTAGGCAGAGACGGAGCCCGGCCCTGCGCCTCCGCACCACGCCCGGGACCCCACCCAGC GGCCCGTACCCGGAGAAGCAGCGCGAGCACCCGAAGCTCCCGGCTGGCGGCAGAAACCGG GAGTGGGGCCGGGCGAGTGCGCGGCATCCCAGGCCGGCCCGAACGCTCCGCCCGCGGTGG GCCGACTTCCCCTCCTCTTCCCTCTCTCCTTCCTTTAGCCCGCTGGCGCCGGACACGCTG CGCCTCATCTCTTGGGGCGTTCTTCCCCGTTGGCCAACCGTCGCATCCCGTGCAACTTTG GGGTAGTGGCCGTTTAGTGTTGAATGTTCCCCACCGAGAGCGCATGGCTTGGGAAGCGAG GCGCGAACCCGGCCCCCGAAGGGCCGCCGTCCGGGAGACGGTGATGCTGTTGCTGTGCCT GGGGGTCCCGACCGGCCGCCCCTACAACGTGGACACTGAGAGCGCGCTGCTTTACCAGGG CCCCCACAACACGCTGTTCGGCTACTCGGTCGTGCTGCACAGCCACGGGGCGAACCGATG GCTCCTAGTGGGTGCGCCCACTGCCAACTGGCTCGCCAACGCTTCAGTGATCAATCCCGG GGCGATTTACAGATGCAGGATCGGAAAGAATCCCGGCCAGACGTGCGAACAGCTCCAGCT GGGTAGCCCTAATGGAGAACCTTGTGGAAAGACTTGTTTGGAAGAGAGAGACAATCAGTG GTTGGGGGTCACACTTTCCAGACAGCCAGGAGAAAATGGATCCATCGTGACTTGTGGGCA TAGATGGAAAAATATATTTTACATAAAGAATGAAAATAAGCTCCCCACTGGTGGTTGCTA TGGAGTGCCCCCTGATTTACGAACAGAACTGAGTAAAAGAATAGCTCCGTGTTATCAAGA TTATGTGAAAAAATTTGGAGAAAATTTTGCATCATGTCAAGCTGGAATATCCAGTTTTTA CACAAAGGATTTAATTGTGATGGGGGCCCCAGGATCATCTTACTGGACTGGCTCTCTTTT TGTCTACAATATAACTACAAATAAATACAAGGCTTTTTTAGACAAACAAAATCAAGTAAA ATTTGGAAGTTATTTAGGATATTCAGTCGGAGCTGGTCATTTTCGGAGCCAGCATACTAC CGAAGTAGTCGGAGGAGCTCCTCAACATGAGCAGATTGGTAAGGCATATATATTCAGCAT TGATGAAAAAGAACTAAATATCTTACATGAAATGAAAGGTAAAAAGCTTGGATCGTACTT TGGAGCTTCTGTCTGTGCTGTGGACCTCAATGCAGATGGCTTCTCAGATCTGCTCGTGGG AGCACCCATGCAGAGCACCATCAGAGAGGAAGGAAGAGTGTTTGTGTACATCAACTCTGG CTCGGGAGCAGTAATGAATGCAATGGAAACAAACCTCGTTGGAAGTGACAAATATGCTGC AAGATTTGGGGAATCTATAGTTAATCTTGGCGACATTGACAATGATGGCTTTGAAGATGT TGCTATCGGAGCTCCACAAGAAGATGACTTGCAAGGTGCTATTTATATTTACAATGGCCG TGCAGATGGGATCTCGTCAACCTTCTCACAGAGAATTGAAGGACTTCAGATCAGCAAATC GTTAAGTATGTTTGGACAGTCTATATCAGGACAAATTGATGCAGATAATAATGGCTATGT AGATGTAGCAGTTGGTGCTTTTCGGTCTGATTCTGCTGTCTTGCTAAGGACAAGACCTGT AGTAATTGTTGACGCTTCTTTAAGCCACCCTGAGTCAGTAAATAGAACGAAATTTGACTG TGTTGAAAATGGATGGCCTTCTGTGTGCATAGATCTAACACTTTGTTTCTCATATAAGGG CAAGGAAGTTCCAGGTTACATTGTTTTGTTTTATAACATGAGTTTGGATGTGAACAGAAA GGCAGAGTCTCCACCAAGATTCTATTTCTCTTCTAATGGAACTTCTGACGTGATTACAGG AAGCATACAGGTGTCCAGCAGAGAAGCTAACTGTAGAACACATCAAGCATTTATGCGGAA AGATGTGCGGGACATCCTCACCCCAATTCAGATTGAAGCTGCTTACCACCTTGGTCCTCA TGTCATCAGTAAACGAAGTACAGAGGAATTCCCACCACTTCAGCCAATTCTTCAGCAGAA GAAAGAAAAAGACATAATGAAAAAAACAATAAACTTTGCAAGGTTTTGTGCCCATGAAAA TTGTTCTGCTGATTTACAGGTTTCTGCAAAGATTGGGTTTTTGAAGCCCCATGAAAATAA AACATATCTTGCTGTTGGGAGTATGAAGACATTGATGTTGAATGTGTCCTTGTTTAATGC TGGAGATGATGCATATGAAACGACTCTACATGTCAAACTACCCGTGGGTCTTTATTTCAT TAAGATTTTAGAGCTGGAAGAGAAGCAAATAAACTGTGAAGTCACAGATAACTCTGGCGT GGTACAACTTGACTGCAGTATTGGCTATATATATGTAGATCATCTCTCAAGGATAGATAT TAGCTTTCTCCTGGATGTGAGCTCACTCAGCAGAGCGGAAGAGGACCTCAGTATCACAGT GCATGCTACCTGTGAAAATGAAGAGGAAATGGACAATCTAAAGCACAGCAGAGTGACTGT AGCAATACCTTTAAAATATGAGGTTAAGCTGACTGTTCATGGGTTTGTAAACCCAACTTC ATTTGTGTATGGATCAAATGATGAAAATGAGCCTGAAACGTGCATGGTGGAGAAAATGAA CTTAACTTTCCATGTTATCAACACTGGCAATAGTATGGCTCCCAATGTTAGTGTGGAAAT AATGGTACCAAATTCTTTTAGCCCCCAAACTGATAAGCTGTTCAACATTTTGGATGTCCA GACTACTACTGGAGAATGCCACTTTGAAAATTATCAAAGAGTGTGTGCATTAGAGCAGCA AAAGAGTGCAATGCAGACCTTGAAAGGCATAGTCCGGTTCTTGTCCAAGACTGATAAGAG GCTATTGTACTGCATAAAAGCTGATCCACATTGTTTAAATTTCTTGTGTAATTTTGGGAA AATGGAAAGTGGAAAAGAAGCCAGTGTTCATATCCAACTGGAAGGCCGGCCATCCATTTT AGAAATGGATGAGACTTCAGCACTCAAGTTTGAAATAAGAGCAACAGGTTTTCCAGAGCC AAATCCAAGAGTAATTGAACTAAACAAGGATGAGAATGTTGCGCATGTTCTACTGGAAGG ACTACATCATCAAAGACCCAAACGTTATTTCACCATAGTGATTATTTCAAGTAGCTTGCT ACTTGGACTTATTGTACTTCTGTTGATCTCATATGTTATGTGGAAGGCTGGCTTCTTTAA AAGACAATACAAATCTATCCTACAAGAAGAAAACAGAAGAGACAGTTGGAGTTATATCAA CAGTAAAAGCAATGATGATTAAGGACTTCTTTCAAATTGAGAGAATGGAAAACAGACTCA GGTTGTAGTAAAGAAATTTAAAAGACACTGTTTACAAGAAAAAATGAATTTTGTTTGGAC TTCTTTTACTCATGATCTTGTGACATATTATGTCTTCATGCAAGGGGAAAATCTCAGCAA TGATTACTCTTTGAGATAGAAGAACTGCAAAGGTAATAATACAGCCAAAGATAATCTCTC AGCTTTTAAATGGGTAGAGAAACACTAAAGCATTCAATTTATTCAAGAAAAGTAAGCCCT TGAAGATATCTTGAAATGAAAGTATAACTGAGTTAAATTATACTGGAGAAGTCTTAGACT TGAAATACTACTTACCATATGTGCTTGCCTCAGTAAAATGAACCCCACTGGGTGGGCAGA GGTTCATTTCAAATACATCTTTGATACTTGTTCAAAATATGTTCTTTAAAAATATAATTT TTTAGAGAGCTGTTCCCAAATTTTCTAACGAGTGGACCATTATCACTTTAAAGCCCTTTA TTTATAATACATTTCCTACGGGCTGTGTTCCAACAACCATTTTTTTTCAGCAGACTATGA ATATTATAGTATTATAGGCCAAACTGGCAAACTTCAGACTGAACATGTACACTGGTTTGA GCTTAGTGAAATTACTTCTGGATAATTATTTTTTTATAATTATGGATTTCACCATCTTTC TTTCTGTATATATACATGTGTTTTTATGTAGGTATATATTTACCATTCTTCCTATCTATT CTTCCTATAACACACCTTTATCAAGCATACCCAGGAGTAATCTTCAAATCTTTTGTTATA TTCTGAAACAAAAGATTGTGAGTGTTGCACTTTACCTGATACACGCTGATTTAGAAAATA CAGAAACCATACCTCACTAATAACTTTAAAATCAAAGCTGTGCAAAGACTAGGGGGCCTA TACTTCATATGTATTATGTACTATGTAAAATATTGACTATCACACAACTATTTCCTTGGA TGTAATTCTTTGTTACCCTTTACAAGTATAAGTGTTACCTTACATGGAAACGAAGAAACA AAATTCATAAATTTAAATTCATAAATTTAGCTGAAAGATACTGATTCAATTTGTATACAG TGAATATAAATGAGACGACAGCAAAATTTTCATGAAATGTAAAATATTTTTATAGTTTGT TCATACTATATGAGGTTCTATTTTAAATGACTTTCTGGATTTTAAAAAATTTCTTTAAAT ACAATCATTTTTGTAATATTTATTTTATGCTTATGATCTAGATAATTGCAGAATATCATT TTATCTGACTCTGCCTTCATAAGAGAGCTGTGGCCGAATTTTGAACATCTGTTATAGGGA GTGATCAAATTAGAAGGCAATGTGGAAAAACAATTCTGGGAAAGATTTCTTTATATGAAG TCCCTGCCACTAGCCAGCCATCCTAATTGATGAAAGTTATCTGTTCACAGGCCTGCAGTG ATGGTGAGGAATGTTCTGAGATTTGCGAAGGCATTTGAGTAGTGAAATGTAAGCACAAAA CCTCCTGAACCCAGAGTGTGTATACACAGGAATAAACTTTATGACATTTATGTATTTTTA AAAAACTTTGTATCGTTATAAAAAGGCTAGTCATTCTTTCAGGAGAACATCTAGGATCAT AGATGAAAAATCAAGCCCCGATTTAGAACTGTCTTCTCCAGGATGGTCTCTAAGGAAATT TACATTTGGTTCTTTCCTACTCAGAACTACTCAGAAACAACTATATATTTCAGGTTATCT GAGCACAGTGAAAGCAGAGTACTATGGTTGTCCAACACAGGCCTCTCAGATACAAGGGGA ACACAATTACATATTGGGCTAGATTTTGCCCAGTTCAAAATAGTATTTGTTATCAACTTA CTTTGTTACTTGTATCATGAATTTTAAAACCCTACCACTTTAAGAAGACAGGGATGGGTT ATTCTTTTTTGGCAGGTAGGCTATATAACTATGTGATTTTGAAATTTAACTGCTCTGGAT TAGGGAGCAGTGAATCAAGGCAGACTTATGAAATCTGTATTATATTTGTAACAGAATATA GGAAATTTAACATAATTGATGAGCTCAAATCCTGAAAAATGAAAGAATCCAAATTATTTC AGAATTATCTAGGTTAAATATTGATGTATTATGATGGTTGCAAAGTTTTTTTGTGTGTCC AATAAACACATTGTAAAAAAAA |
Protein Sequence | >3676 : length: 1032 MAWEARREPGPRRAAVRETVMLLLCLGVPTGRPYNVDTESALLYQGPHNTLFGYSVVLHS HGANRWLLVGAPTANWLANASVINPGAIYRCRIGKNPGQTCEQLQLGSPNGEPCGKTCLE ERDNQWLGVTLSRQPGENGSIVTCGHRWKNIFYIKNENKLPTGGCYGVPPDLRTELSKRI APCYQDYVKKFGENFASCQAGISSFYTKDLIVMGAPGSSYWTGSLFVYNITTNKYKAFLD KQNQVKFGSYLGYSVGAGHFRSQHTTEVVGGAPQHEQIGKAYIFSIDEKELNILHEMKGK KLGSYFGASVCAVDLNADGFSDLLVGAPMQSTIREEGRVFVYINSGSGAVMNAMETNLVG SDKYAARFGESIVNLGDIDNDGFEDVAIGAPQEDDLQGAIYIYNGRADGISSTFSQRIEG LQISKSLSMFGQSISGQIDADNNGYVDVAVGAFRSDSAVLLRTRPVVIVDASLSHPESVN RTKFDCVENGWPSVCIDLTLCFSYKGKEVPGYIVLFYNMSLDVNRKAESPPRFYFSSNGT SDVITGSIQVSSREANCRTHQAFMRKDVRDILTPIQIEAAYHLGPHVISKRSTEEFPPLQ PILQQKKEKDIMKKTINFARFCAHENCSADLQVSAKIGFLKPHENKTYLAVGSMKTLMLN VSLFNAGDDAYETTLHVKLPVGLYFIKILELEEKQINCEVTDNSGVVQLDCSIGYIYVDH LSRIDISFLLDVSSLSRAEEDLSITVHATCENEEEMDNLKHSRVTVAIPLKYEVKLTVHG FVNPTSFVYGSNDENEPETCMVEKMNLTFHVINTGNSMAPNVSVEIMVPNSFSPQTDKLF NILDVQTTTGECHFENYQRVCALEQQKSAMQTLKGIVRFLSKTDKRLLYCIKADPHCLNF LCNFGKMESGKEASVHIQLEGRPSILEMDETSALKFEIRATGFPEPNPRVIELNKDENVA HVLLEGLHHQRPKRYFTIVIISSSLLLGLIVLLLISYVMWKAGFFKRQYKSILQEENRRD SWSYINSKSNDD |