LKB1 interacts only with active form of cdc42 and PAK, but not with inactive cdc42. Taken together, these results show that LKB1 is a critical mediator of the NSCLC polarity program in lung cancer cells through a novel LKB1-cdc42-PAK pathway.

delta-catenin facilitated invasion of lung cancer cells by upregulating the mRNA and protein levels of cdc42

Data suggest a potential therapeutic role for curcumin in inducing Cdc42-mediated inhibition of invasion of lung cancer cells.

Data suggest that microRNA 137 influences cell proliferation via regulation of expression of CDC42 and CDK6 (cyclin-dependent kinase 6); expression of microRNA 137 in lung cancer cells downregulates CDC42/CDK6 and induces G1 cell cycle arrest.

MDA-9 upregulated active levels of known modulators of epithelial mesenchymal transformation, the small GTPases RhoA and Cdc42, via TGFbeta1, promoting lung metastasis of breast cancer cells.

loss of XIAP enhances filopodia formation in a Cdc42-dependent manner and this phenomenon phenocopies EGF stimulation. Further, XIAP depletion promotes lung colonization of tumor cells in mice in a Cdc42-dependent manner. These observations shed molecular insights into ubiquitin-dependent regulation of Cdc42 and that of actin cytoskeleton.

Data show that CDC42 functions in a cell-type specific manner in lung tumorigenesis in contrast with different cell lineages. Loss of Cdc42 promoted KRAS-induced Club cell tumor formation, underscoring an important tumor initiation function of polarity loss which was previously considered a by-product of abnormal cell accumulation.