Links to all GeneRIF Items | 9965 |
PubMed (Gene Name) | Literature evidence |
|---|---|
| 17599042 (FGF19) | FGF19 is coexpressed with its cognate receptor FGFR4 in primary human liver, lung, and colon tumors and in a subset of human colon cancer cell lines, where their interactions are important for tumor growth. |
| 28906590 (FGF19) | Study showed that FGF19 amplification is a genetic event in Chinese lung squamous cell carcinoma (LSCC) patients, with a frequency of 37.5%. FGF19 amplified LSCC cells express relatively higher levels of FGF19 mRNA expression, and downregulation of FGF19 expression can induce significant cell killing effects in vitro and in vivo. |
| 32111983 (FGF19) | Enhanced autocrine FGF19/FGFR4 signaling drives the progression of lung squamous cell carcinoma, which responds to mTOR inhibitor AZD2104. |