Overexpression of miR-200b led to the downregulation of ZEB2 at protein level so our results suggested that ZEB2 regulated by miR-200b may contribute to multi-drug resistance of small cell lung cancer.

results highlight a feedback loop between miR-203 and ZEB2, which participates in the pathogenesis of lung adenocarcinoma

overexpression of miR-218 in H1299 increased chemosensitivity of cells to cisplatin treatment through suppression of Slug and ZEB2. These findings highlight an important role of miR-218 in the regulation of EMT-related traits and metastasis of lung cancer in part by modulation of Slug/ZEB2 signaling, and provide a potential therapeutic strategy by targeting miR-218 in lung cancer.

Results show that ZEB2 is highly expressed in small cell lung cancer (SCLC) tissue samples and consistent with E2F1 expression. Also, further data showed that E2F1 regulated ZEB2 expression through E2F1 binding sites on the promoter of ZEB2 in SCLC.

MiR-138-5p inhibits epithelial-mesenchymal transition, growth and metastasis of lung adenocarcinoma cells through targeting ZEB2.

Low ZEB2 expression is associated with Non-Small Cell lung cancers.

MicroRNA-507 represses the malignant behaviors of non-small cell lung cancer via targeting zinc finger E-box binding homeobox 2.