Autocrine/paracrine prostaglandin E2 production by non-small cell lung cancer cells regulates antigen in cox-2-dependent invasion

Increased CD44 antigen is associated with relapses in non-small cell lung cancers

Crucial participants in tumour invasion and metastases are matrix metalloproteinases, tissue inhibitor of metalloproteinase inhibitors and cellular adhesion molecules. They play roles in tumour invasion and metastasis in non-small-cell lung carcinomas.

E-cad, CD44v6 and PCNA play important roles in invasion and metastasis of non-small cell lung cancer (NSCLC).

Results demonstrated that stem cell-like properties are enriched in CD44-expressing subpopulations of some lung cancer cell lines.

CD44s and CD44v6 are expressed in certain types of lung cancer; in adenocarcinoma CD44s and CD44v6 expression is significantly correlated with lymph node metastases and tumor size

Data suggest that pulmonary metastasis is corrected with levels of Geminin, cleaved caspase-3, CD44, E-cadherin, epidermal growth factor receptor, and CD204 in cancer cells within permeated lymphatic vessels.

Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell.

Ezrin, E-cadherin and CD44V6 play an important role in the regulation of growth and meastasis of lung cancer.

levels of CD133, CD44, and ALDH1 had independent prognostic value to predict the recurrence of lung adenocarcinoma

Interactions between CD44 expressing breast cancer cells and soluble factors present in the lung microenvironment may play an important role in determining organotropic metastatic behavior.

Our meta-analysis showed that CD44-V6 is an efficient prognostic factor for non-small cell lung cancer

CD44v6 high expression as a poor prognostic factor for non-small cell lung cancer, and CD44v6 expression is associated with lymph node metastasis and histopathologic type.

CD44 could be a valuable tool for the study of lung CSCs and provide a novel therapeutic target for treatment of the patients with lung cancer in combination with conventional therapy.

findings support the value of CD44v6 as a possible indicator of poor outcome in patients with squamous lung carcinomas.

CD44, both a functional biomarker and therapeutic target, promoted CD133(+) CD44(+) lung cancer stem cell-like cells metastasis by Wnt/beta-catenin-FoxM1-Twist signaling.

the authors investigated the ability of two hyaluronan-based nanoparticles targeting CD44 receptors to home in on lung cancer cells in an in-vivo orthotropic model. The preferential uptake of smaller sized nanoparticles via intravenous route has further enhanced the existing knowledge of future drug designs.

Analysis of KRAS mutation combined with immunohistochemical expression of CD44 and CD166 identified subgroups of patients with colon adenocarcinoma at higher risk of lymph node involvement by the tumor and development of liver and lung metastasis.

that ITGbeta3 and CD44 expression levels determine whether OPN-a inhibits or enhances growth in lung cancer cells.

ZEB1-induced epithelial-to-mesenchymal transition and associated molecular changes in ESRP1 and CD44 contribute to early pathogenesis and metastatic potential in established lung cancer

Peripheral blood lymphocyte subsets in patients with lung cancer are different from those in healthy people, and circulating CD44+ and CD54+ lymphocytes seem to be a promising criterion to predict survival in lung cancer patients undergoing chemotherapy

DGCR5 can act as a crucial regulator of cancer stem cells in non small cell lung cancer by modulating miR-330-5p/CD44 axis.

High CD44v9 expression in EGFR-mutant tumors are associated with lung Adenocarcinoma

CD44 Promotes PD-L1 expression and Its tumor-Intrinsic Function in Breast and lung cancers.

CD44 inhibition attenuates EGFR signaling and enhances cisplatin sensitivity in human EGFR wildtype nonsmallcell lung cancer cells.

CD44 Gene Polymorphisms as a Risk Factor for Susceptibility and Their Effect on the Clinicopathological Characteristics of lung Adenocarcinoma in Male Patients.

Clinical Significance of tumour CD44v and MIST1 expression in Patients With Non-small-cell lung cancer.

these results reveal an unrecognized role for CD44 in oncogenic Kras-induced lung adenocarcinoma and suggest that targeting CD44 could be an effective strategy for halting Kras-dependent carcinomas.

depletion of CD44s inhibits breast cancer cell metastasis to the lung in animals. These findings suggest a crucial mechanism underlying the role of the CD44s splice isoform in breast cancer metastasis.