role in transport of 7-ethyl-10-hydroxycamptothecin (SN-38) in human lung cancer cells

BCRP may serve as a molecular target for reducing drug resistance to chemotherapy in advanced lung cancer patients.

RALBP1 and ABCG2 transport doxorubicin differently in lung and breast cancer cell lines

Determination of P-glycoprotein, MDR-related protein 1, breast cancer resistance protein, and lung-resistance protein expression in leukemic stem cells of acute myeloid leukemia.

High BCRP expression was associated with drug resistance to platinum-based chemotherapy in non-small-cell lung cancer.

ABCC3 C-211T and ABCG2 C421A as candidate transporter SNPs to be further investigated as possible predictors of the clinical outcome of chemotherapy in lung cancer patients.

non-small cell lung carcinoma patients with the dual expression of CD133 and ABCG2 have a high risk of early relapse

Downregulated ABCG2 enhances sensitivity to topoisomerase I inhibitor in epidermal growth factor receptor tyrosine kinase inhibitor-resistant non-small cell lung cancer.

low BCRP in metastatic cells are associated with response to therapy in small cell lung cancer.

study characterized genetic variability of the ABCB1 (also known as MDR1), ABCC2 (MRP2) and ABCG2 (BCRP) genes, which are key players in the metabolism of many chemotherapeutic agents including those used in the treatment of lung cancer

Suggest that ABCG2 34G>A would be useful for predicting grade 2 or worse skin rash in non-small cell lung carcinoma patients treated with gefitinib.

Results demonstrate that Sp1 and Sp3 transcription factors are the primary determinants for activating basal transcription of the ABCG2 gene and play an important role in maintaining the side population phenotype of lung cancer cells.

Findings suggest that ABCG2 is involved in the modulation of cancer drug resistance to cisplatin by regulating the pattern of cell division in non small cell lung carcinoma.

Our data suggest that Nrf2-mediated ABCG2 over expression in lung adenocarcinoma SP (side population) cells might responsible for chemotherapy failure

Patients with quick chemoresistance lung adenocarcinoma displayed an elevated level of serum cholesterol and their tumors showed upregulated ABCG2 expression.

ABCG2 localizes to the nucleus and modulates CDH1 expression in lung cancer cells

Pelitinib (EKB-569) targets the up-regulation of ABCB1 and ABCG2 induced by hyperthermia to eradicate lung cancer

ABCG2 rs3114020 might be one of the candidate biomarkers for non-small cell lung cancer survival in this Chinese population, especially among patients with adenocarcinoma.

Results found ABCG2 overexpressed in lung cancer side population cells. Its expression is regulated YAP1 at the transcriptional level through binding to its promoterregion.