High levels of netrin-1 found in 43 of the 92 NSCLC tumor samples. Interference with netrin-1 in human lung cancer cell lines was associated with UNC5H-mediated cell death in vitro and with tumor growth inhibition and/or regression in xenografted mice.

Data show that netrin-1 concentrations elevated in advanced non-small cell lung cancer compared to a healthy control group, and netrin-1 concentrations decreased with chemotherapy.

the current data suggest that netrin-1 can act as a pro-metastatic factor in NSCLC by enhancing cell invasion, migration, and VM via PI3K/AKT and ERK-mediated EMT process, thereby implicating netrin-1 as a novel promising therapeutic target against aggressive non-small cell lung cancer.

Netrin1 mediated epithelialmesenchymal transition of A549 and PC9 cells in vitro, which may be associated with the PI3K/AKT pathway. This effect was not observed under normoxic conditions. Serum concentration of netrin1 was found to be significantly higher in nonsmall cell lung cancer (NSCLC) patients compared with healthy donors. Findings highlight a novel role for netrin1 in NSCLC development under hypoxia.

IGF2BP1 silencing inhibits proliferation and induces apoptosis of high glucose-induced non-small cell lung cancer cells by regulating Netrin-1.