astrocyte-elevated gene-1 plays a crucial role in the carcinogenesis and aggressiveness of non-small cell lung cancer, promoting its metastasis by modulating matrix metalloproteinase-9 expression and leading to a poor clinical prognosis.

our results indicated that AEG-1 played a crucial role in the carcinogenesis of non-small cell lung cancer

our results suggest that the evodiamine suppress the proliferation of lung cancer cells, at least, in part, via inhibition of MTDH expression and activation of apoptosis.

In patients with non-small cell lung cancer, AEG-1 expression was an independent prognostic factor for both overall and disease-free survival.

Data showed that AEG1 and MMP7 levels were both significantly increased and strongly correlated in non-small cell lung cancer (NSCLC) tissues. AEG-1 promotes NSCLC cell invasiveness through MAPK-p42/p44-dependent activation of MMP7.

Gene expression data and in silico database analysis showed that the metadherin gene (MTDH) was a direct target of both miR-145-5p and miR-145-3p regulation and high expression of MTDH predicted poorer survival of lung squamous cell carcinoma patients.

miR-384 and AEG-1 may serve as potential targets for the diagnosis and treatment of non-small-cell lung cancer.

AEG-1 may play important roles at the transcription level in malignant transformation and tumor angiogenesis in non-small cell lung cancer.

Data indicate that circMTDH.4/miR-630/astrocyte elevated gene-1 (AEG-1) axis is responsible for chemoresistance and radioresistance in non-small-cell lung cancer (NSCLC) cells.

Long non-coding RNA PRNCR1 modulates non-small cell lung cancer cell proliferation, apoptosis, migration, invasion, and EMT through PRNCR1/miR-126-5p/MTDH axis.

Therapeutic Targeting of Metadherin Suppresses Colorectal and lung cancer Progression and Metastasis.