Overexpression of aurora B kinase leading to genetic instability is associated with primary non-small cell lung carcinoma

AURB is a novel target of transcriptional regulation by histone deacetylase inhibitors in non-small cell lung cancer.

Aurora-B protein is highly expressed in non-small cell lung cancer, and was associated with lymph node metastasis, differentiation and histological type.

Data indicate that Aurora-B overexpression may contribute to malignant potential and increased aneuploidy in non-small-cell lung cancer (NSCLC) and may serve as a new therapeutic target in against NSCLC.

Data indicate the antitumor and radiosensitizing activity of daurinol in lung cancer cells through the inhibition of aurora kinase A/B (AURKA and AURKB).

Aurora kinases are important KRAS targets in lung cancer.

We also suggested Aurora-B as a promising therapeutic target in non-small cell lung cancer treatment.

Study have demonstrated that acquisition of resistance to EGFR tyrosine kinase inhibitors in EGFR-mut cell line models and non-small cell lung cancer patients is often associated with AURKB activation and increased levels of histone H3 phosphorylation.

Loss of Aurora Kinase Signaling Allows lung cancer Cells to Adopt Endoreplication and Form Polyploid Giant cancer Cells That Resist Antimitotic Drugs.