overexpressed cyclin B1, veiling the effect of cyclin D1 or cyclin E, mediated nickel-caused M-phase blockage and cell growth inhibition, which may render pulmonary cells more sensitive to DNA damage and facilitates cancer initiation

Cyclin B1 and cyclin A are aberrantly expressed in non-small cell lung cancer and some precursor lesions. Cyclin B1, but not cyclin A, shows some promise as a potential prognostic marker in non-small cell lung cancer.

ZIC5 is highly upregulated in non-small cell lung cancer tumor tissues and may act as an oncogene by influencing CCNB1 and CDK1 complex expression

High expression of CCNB1 was specifically associated with poor survival in lung adenocarcinoma.

sticky siRNAs against survivin and cyclin B1 efficiently blocks growth of established subcutaneaous B16-F10 tumors as well as formation and dissemination of melanoma lung metastases.