Findings demonstrate a role of SPHK1 activation in proinflammatory signalling and of SPHK1 basal activity in survival of A549 lung carcinoma cells.

Data suggest that sphingosine kinase 1 (SPHK1) is involved in the regulation of small cell lung cancer multi-drug resistance, and a target gene to evaluate the chemosensitivity and clinical prognostic for small cell lung cancer (SCLC).

HULC expression level was increased in non-small cell lung cancer (NSCLC) tissues compared with healthy tissues. Serum level of HULC was higher in cancer patients than that in healthy control and was increased with stage of primary tumor. LncRNA HULC overexpression can promote NSCLC cell proliferation and inhibit cell apoptosis by up-regulating SPHK1 and further induce the activation of its downstream PI3K/Akt pathway.

Increased SPK1 expression promotes cell growth by activating the ERK1/2 signaling in non-small-cell lung cancer.

SPHK1 is highly expressed in triple-negative breast cancer and promotes spontaneous lung metastasis.