findings show that E2F1 triggers apoptosis in lung adenocarcinoma cell lines by a mechanism involving the specific downregulation of the cellular FLICE-inhibitory protein short, leading to caspase-8 activation at the death-inducing signaling complex

inhibition of c-FLIP(L) expression might be a potential strategy for lung cancer therapy, especially for those lung cancers resistant to the agonistic antibody against death receptors

FADD-Like Apoptosis Regulating Protein silencing sensitized non-small-cell lung cancer cells but not normal cells to chemotherapy in vitro, and silencing FLIP in vivo retarded non-small-cell lung cancer cells xenograft.

Epidermal growth factor receptor-mediated tissue transglutaminase overexpression couples acquired tumor necrosis factor-related apoptosis-inducing ligand resistance and migration through c-FLIP and MMP-9 proteins in lung cancer cells

High c-FLIP expression is associated with lung cancer.

Inhibition of BET bromodomain-dependent XIAP and FLIP expression sensitizes KRAS-mutated non-small cell lung cancer to pro-apoptotic agents.

Cordycepin induces apoptosis through autophagy-mediated downregulation of c-FLIPL in human non-small cell lung carcinoma cells.

High c-FLIP expression is associated with lung squamous cell carcinoma.