results suggest that loss of RUNX3 expression by DNA hypermethylation is frequently associated with the evolution of lung cancer

The expression of RUNX3 protein in lung AC might play a pivotal role in tumor progression and patients' survival

RUNX3 is downregulated by hemizygous deletion at 1p36 in human lung cancer cell lines

RUNX3 gene plays an important role in the pathogenesis of lung cancer, and aberrant methylation is an important mechanism of inactivation of the RUNX3 gene in lung AdC.

the hypermethylation of RUNX3 gene is a useful biomarker to predict the prognosis in non-small cell lung cancer

Runx3 is essential for lung epithelial cell differentiation, and that downregulation of Runx3 is causally linked to the preneoplastic stage of lung adenocarcinoma.

RUNX3 methylation is a significant independent prognostic factor for disease-free survival and overall survival in non-small cell lung cancers.

Aim of this study was to characterize further the expression of RUNX3 in lung cancers.Inactivation of RUNX3 was observed in 70% of the adenocarcinoma samples, and this was associated with promoter hypermethylation but not biased to EGFR/KRAS mutations.

epigenetic downregulation of RUNX3 can induce docetaxel resistance in human lung adenocarcinoma cells by activating AKT signaling.

Inactivation of RUNX3 induces lung neoplasms and greatly accelerates the K-RAS-induced development of adenocarcinoma.

RUNX3 hypermethylation is associated with an increased risk and worse survival in non-small cell lung cancer

we show that RUNX3 and RUNX3-regulated chemokines are linked to non-small cell lung cancer-mediated bone resorption

Overexpression of miR-4286 is an unfavorable prognostic marker in individuals with non-small cell lung cancer.

Studies identify RUNX3 as a novel target gene of miR-301a in non-small cell lung carcinoma cell lines and Kras mutated mice. Elevated RUNX3 expression contributes to attenuated cellular migration in lung cancer cells with miR-301a inhibition and reduced lung tumorigenesis in miR-301a deficient mice.

Runx3 is involved in crucial regulation of alveolar differentiation and tumor suppression in developing mouse lung.

Study using Runx3 heterozygous mice hindlimb ischemic model and Lewis lung carcinoma cell allograft model revealed that Runx3 inhibits vasculogenesis via the inhibition of endothelial progenitor cells differentiation and function via the suppression of Hif1alpha activity.