Up-regulated caveolin-1 accentuates the metastasis capability of lung adenocarcinoma by inducing filopodia formation.

In head and neck squamous cell carcinoma, cav-1 may play an inhibitory role in tumorigenesis and lung metastasis through regulating integrin beta1- and Src-mediated cell-cell and cell-matrix interactions.

Increased caveolin 1 is associated with metastatic lymph node sites in non-small-cell lung cancer.

Cav-1 is a novel immunohistochemical marker for the differentiation of epithelioid mesothelioma from lung adenocarcinoma.

Cav-1 immunoreactivity in lung carcinoma is histotype-dependent and acquired de novo in brain metastases, suggesting a site-specific phenotypic shift in secondary lesions.

might increase small cell lung cancer metastasis potential through the interaction with E-cadherin and MMP-3 genes

reactive oxygen species and caveolin-1 have roles in lung cancer cell migration and invasion

Caveolin-1 plays a key role as a negative regulator of anoikis through a reactive oxygen species-dependent mechanism in human lung carcinoma H460 cells.

Cav-1 immunoreactivity in lung cancer is histotype-dependent, increased Cav-1 expression indicates the malignant progression and high invasion features of non-small cell lung carcinomas.

sensitivity of non-small-cell lung cancer cells to metformin was dependent on Cav-1 expression

Higher Cav1 expression correlated with the advanced pathological stage and shorter survival rates in lung adenocarcinoma patients.

A novel role of Cav-1 protein is the suppression of cellular oxidative stress induced by hydrogen peroxide in lung carcinoma.

CAV-1 affected cell growth of lung cancer NCI-H446 cell through the interactions with p-ERK1/2, estrogen receptor and progestin receptor

Data suggest that down-regulation of CAV1 suppresses proliferation of lung carcinoma cells and may promote metastasis of lung tumors.

Cav-1 is the key regulator of anchorage independent growth and anoikis resistance in lung carcinoma cells.

Caveolin-1 expression is decreased in samples of non-small cell lung cancer.

Cav-1 plays a duplex role in tumorigenesis and tumor progression in non-small cell lung cancer

The expression of caveolin-1 was positively correlated with an advanced pathologic stage. Thus, caveolin-1 could act as a predictor of a poor prognosis in patients with large cell lung carcinoma

higher protein expression in tumor is associated with both improved response rate and overall survival in advanced non-small-cell lung cancer

caveolin-1 represents one of the genes whose expression is strongly activated by Np73beta in non-small lung cancer cells

High CAV1 expression is associated with lung cancer.

caveolin-1 expression in cancer associated fibroblasts was significantly associated with a poor outcome in lung adenocarcinoma.

Results indicate that cordycepin promotes caveolin-1 (CAV1)upregulation to enhance c-jun N-terminal kinase (JNK)/forkhead box O3A protein (Foxo3a) signaling pathway activation, inducing apoptosis in lung cancer cells.

Data highlight that Caveolin 1 expression confers a proliferative advantage in lung adenocarcinoma cells, thus fostering increased tumor aggressiveness.

These results suggest that Cav-1 may be a predictor of the poor efficacy of EGFR-TKIs treatment in lung adenocarcinoma with EGFR mutations.

we revisited the question of the relationship between Cav1 and Stat3-ptyr705 in non-transformed mouse fibroblasts and in human lung carcinoma cells, by examining their effect at different cell densities.Our results demonstrate that Cav1 downregulates cadherin-11, by a mechanism which requires the Cav1 scaffolding domain. This cadherin-11 downregulation, leads to a reduction in cRac1 and Stat3 activity levels.

High CAV1 expression is associated with Small Cell lung cancer.

stromal expression of CAV1 in primary tumors was not associated with clinical outcome whereas the stromal expression of especially CAV2 in the metastatic lymph nodes could be associated with lung cancer pathogenesis.

Protein-protein interaction network analysis indicated that caveolin 1 (CAV1) and decorin (DCN) levels were significantly reduced and that these genes were the most promising predictive biomarkers for the occurrence and prognosis of lung adenocarcinoma.

CAV1 - GLUT3 signaling is important for cellular energy and can be targeted by Atorvastatin in Non-Small Cell lung cancer.

A novel TRPM7/O-GlcNAc axis mediates tumour cell motility and metastasis by stabilising c-Myc and caveolin-1 in lung carcinoma.

The inhibitory effect of microRNA-1827 on anoikis resistance in lung adenocarcinoma A549 cells via targeting caveolin-1.

caveolin-1 overexpression yields defective parenchymal epithelia in multiple exocrine organs and increased susceptibility to carcinogenesis including lung and liver carcinomas and lymphoma.

data suggest that lung cancer cells escape oncogene-induced premature senescence through down-regulation of caveolin-1 expression to progress from premalignant lesions to cancer.