Both mRNA and protein levels of Beclin-1 and LC3-II were significantly decreased in lung cancer tissues which suggested that autophagy may be involved in the pathogenesis of lung cancer.

LC3 and p62/SQSTM1 have roles in early-stage non-small cell lung cancer

The results suggest that autophagy-associated proteins LC3A, LC3B, and Beclin-1 might be potential biomarkers for subclassification, differentiation, and local metastasis in primary lung tumor.

expression and Clinical Significance of LC-3 and P62 in Non-small Cell lung cancer

study suggests that stone-like structures as assessed by LC3A immunohistochemistry as well as LC3A mRNA expression has a clinically relevant negative prognostic value in patients with resected non-small cell lung cancer