regulation of alternative splicing in lung adenocarcinoma cells by de novo ceramide

caspase-3, -8, and -9 activity is enhanced by safrole oxidase in lung cancer cells

Results suggest that CASP-9 promoter polymorphisms affect CASP-9 expression and contribute to genetic susceptibility to lung cancer.

These data indicate that the caspase-9 gene is rarely mutated in gastric, colorectal and lung adenocarcinomas, and suggest that caspase-9 gene mutation may not contribute to the pathogenesis of these cancers.

Study confirms the association between CASP9 gene and non-small cell lung cancer oncogenesis, rs1052576 which locates in exon 5 of CASP9 gene is associated with NSCLC.

Single Nucleotide Polymorphisms in CASP9 is asspciated with lung cancer.

caspase 9 rs4645978 most contributes to decreased susceptibility to cancer in Caucasians and prostate cancer. rs105276, the A allele might be a protective factor for cancer for Asians. rs4645981 confers increased susceptibility to lung cancer in Asians.

Studied the mechanism of Artemisinin (ARTE)-induced human lung adenocarcinoma (ASTC-a-1) cell apoptosis; results showed ARTE induced the activation of caspase-3, -8 and -9.

High CASP9 expression is associated with lung tumorigenesis.

Serum CASP9 levels were significantly lower in the patients group than in the control group (p<0.0001). CASP9 Ex5+32 GG genotype was a risk factor whereas the variant A allele could be a risk-reducing factor for Non-small cell lung cancer .

Mitochondria-cytochrome C-caspase-9 cascade mediates isorhamnetin-induced apoptosis in Lewis lung carcinoma.

Results identify a cancer-specific mechanism of hnRNP L phosphorylation and subsequent lowering of the caspase-9a/9b ratio, which is required for the tumorigenic capacity of non-small cell lung cancer cells.