Small interfering RNA-mediated downregulation of SRC-3 in high-expressing, but not in low-expressing, lung cancer cells significantly inhibited tumor cell growth and induced apoptosis.

results demonstrate a high frequency of SRC-3 overexpression in non-small cell lung cancer (NSCLC) with a gender difference, suggesting that there is a specific role for SRC-3 in the pathogenesis of NSCLC

A previously unknown role for ERK3 in promoting lung cancer cell invasiveness by phosphorylating SRC-3 and regulating SRC-3 proinvasive activity by site-specific phosphorylation.

Here, we reported the novel finding that depletion of SRC-3 enhanced sensitivity of breast and lung cancer cells to HDAC inhibitors (SAHA and romidepsin). In contrast, overexpression of SRC-3 decreased SAHA-induced cancer cell apoptosis. Furthermore, we found that SRC-3 inhibitor bufalin increased cancer cell apoptosis induced by HDAC inhibitors. The combination of bufalin and SAHA was particular efficient in attenuating

study demonstrated that inhibition of the deacetylase Rac3 in human lung cancer cells induces autophagy

All WT/PyMT mice developed massive lung metastasis, but AIB1(-/-)/mouse mammary tumor virus-polyomavirus middle T mice with comparable mammary tumors had significantly less lung metastasis.