Ectopic expression of let-7 miRNA reduced HMGA2 and cell proliferation in a lung cancer cell.

HMGA2 overexpression is associated with non-small cell lung cancer

HMGA2 is an oncogene important in the pathogenesis of human lung cancer

High HMGA2 expression is associated with the proliferation and invasion of non-small cell lung cancer.

miR-219 functions as a tumor suppressor and may be important in inhibiting the growth and metastasis of Non-small cell lung cancer cells via directly targeting HMGA2.

Results showed that HMGA2 was upregulated and associated with lung adenocarcinoma (LAC) prognosis. HMGA2, regulated by miR-195, could directly regulate cell motility and proliferation in LAC cells.

LSINCT5 may possibly contribute to non-small cell lung cancer tumorigenesis by stabilizing the oncogenic factor of HMGA2.

lncRNA DANCR was upregulated in lung adenocarcinoma (LAD) tissue and cell lines, compared with paratumor tissue and a normal lung cell line. Additionally, elevated DANCR expression was associated with poor prognosis in the patients with LAD. In LAD cell lines DANCR promoted the invasion of lung adenocarcinoma cells by positively regulating HMGA2.

the findings of the present study demonstrated that miR495 was downregulated in nonsmall cell lung cancer tissues and cells. In addition, miR495 suppressed the proliferation of lung cancer cells by directly targeting HMGA2

HMGA2 regulates circular RNA ASPH to promote tumor growth in lung adenocarcinoma.