results provide evidence for an overexpression of ADAM-12 and a lower expression of ADAMTS-1 in non-small-cell lung cancer suggest that these proteases play different functions in cancer progression

ADAM12-L mRNA expression is an independent prognostic factor in resected stage I lung adenocarcinoma, and is significantly correlated with tumor differentiation stage and postoperative cancer recurrence.

Conditioned medium from A549 human lung adenocarcinoma cells induced the expression of ADAM12, a disintegrin and metalloproteases family member, in human adipose tissue-derived mesenchymal stem cells.

ADAM-12 is an independent prognostic factor and diagnostic marker, and is involved in the proliferation, invasion and metastasis of small cell lung cancer .

This work links ADAM12S to glucose metabolic pathways in its attribution to the tumorigenesis and metastasis of Small Cell lung cancer Cells