TIPE2 might serve as a tumor suppressor in non-small cell lung cancer progression.

TIPE2 promoted lung cancer cell apoptosis through affecting apoptosis-related molecules caspase-3, caspase-9, Bcl-2 and Bax, possibly via regulating P38 and Akt pathways.

TIPE2 suppressed tumor invasiveness and angiogenesis in non-small cell lung cancer via inhibiting the activation of Rac1 and subsequently weakening its downstream effects, including F-actin polymerization and VEGF expression.

TIPE2 Induced the Proliferation, Survival, and Migration of lung cancer Cells Through Modulation of Akt/mTOR/NF-kappaB Signaling Cascade.

aberrant TIPE2 expression may contribute to the occurrence of chemoresistance by interfering with autophagy in non-small-cell lung cancer in an mTOR-dependent manner.

Protective Effect of Dexmedetomidine on Acute lung Injury via the Upregulation of tumour Necrosis Factor-alpha-Induced Protein-8-like 2 in Septic Mice.

expression and regulation of tumor necrosis factor-alpha-induced protein-8-like 2 is associated with acute lung injury induced by myocardial ischemia reperfusion in diabetic rats.