lung cancer gene and literature database Home
Cancer metastasis database

Annotation category 5

Literatures

Literature evidence

Links to all GeneRIF Items

79139

PubMed (Gene Name)

Literature evidence

23306155 (DERL1)

Derlin-1 is overexpressed in non-small cell lung cancer and promotes invasion by EGFR-ERK-mediated up-regulation of MMP-2 and MMP-9.

29530993 (DERL1)

Overexpression of Derlin-1 is Associated with Non-small Cell lung cancer.

29768262 (DERL1)

These findings for the first time revealed that miR-598, as a tumor suppressor, negatively regulate DERL1 and Epithelial-Mesenchymal Transition to suppress the invasion and migration in Non-Small Cell lung cancer (NSCLC), thereby putatively serving as a novel therapeutic target for NSCLC clinical treatment.