altered expression of DDR1 may contribute to malignant progression of non-small cell lung carcinoma

alpha5(IV), but not alpha1(IV), promotes lung cancer cell proliferation and tumor angiogenesis through non-integrin collagen receptor DDR1-mediated ERK activation.

Data suggest that IGF-I/IGF-IR system triggers stimulatory actions through both GPER and DDR1 in aggressive tumors as mesothelioma and lung tumors.

Study showed that bladder tumor cells expressing the collagen receptor, CD167a or Discoidin domain receptor 1, responded to collagen I stimulation at the primary tumor to promote local invasion and utilized the same receptor to preferentially colonize at airway smooth muscle cells - a rich source of collagen III in lung.

Identification of a novel synthetic lethal vulnerability in non-small cell lung cancer by co-targeting TMPRSS4 and DDR1.

Discoidin Domain Receptors, DDR1b and DDR2, Promote tumour Growth within Collagen but DDR1b Suppresses Experimental lung Metastasis in HT1080 Xenografts.