Links to all GeneRIF Items | 7520 |
PubMed (Gene Name) | Literature evidence |
|---|---|
| 17289874 (XRCC5) | low mRNA and protein expression in the BRCA1/BRCA2 and XRCC5 genes occur in lung adenocarcinoma and squamous cell carcinoma, respectively, and promoter hypermethylation is the predominant mechanism in deregulation of these genes |
| 21663524 (XRCC5) | lung carcinoma tissue had higher Ku80 mRNA & protein levels than normal tissue. lung adenocarcinoma & lung squamous carcinoma had higher levels of Ku80 protein & mRNA, than small-cell lung carcinoma. |
| 23181744 (XRCC5) | Ku80 expression level could predict the outcome and the sensitivity to cisplatin-based chemotherapy in patients with lung adenocarcinoma |
| 26358256 (XRCC5) | XRCC5 (rs1051685, rs6941) and AQP2 (10875989, rs3759125) polymorphisms were associated with hematologic toxicity of platinum-based chemotherapy in lung cancer patients |
| 28399858 (XRCC5) | Ku80 could predict the probability of resistance to neoadjuvant chemotherapy in lung adenocarcinoma, and reduced cisplatin and pemetrexed-induced apoptosis in A549 cells |