Genetic polymorphism in XPC gene is associated with lung cancer

The findings support the hypothesis that these two XPC variants may contribute to the risk of developing lung cancer.

Results show that hypermethylation of the XPC promoter may play a crucial role in XPC inactivation, which may partly contribute to the occurrence of p53 mutations during lung tumorigenesis, especially nonsmokers.

results suggest that inherited sequence variations in XPC may modulate risk of lung cancer, especially lung adenocarcinoma, in Chinese populations

Results suggest that reduced XPC mRNA level may constitute an independent prognostic factor for nonsmall cell lung cancer patients.

Low-XPC mRNA may predict relapse in lung cancer patients who are never-smokers

XPC polymorphisms is associated with lung cancer susceptibility.

Female carrying XPC and XRCC1 polymorphic genotypes had significantly increased risk of lung cancer.

meta-analysis suggests that XPC Lys939Gln polymorphism may contribute to lung cancer risk, which needs further validation in single larger studies

we found that Gln939Gln genotype was associated with significantly increased risk of lung cancer in Asian population.

Study results demonstrated that XPC expression was linked with cisplatin resistance in lung cancer cells and that the reversal of the resistance was mainly mediated by the Akt/mTOR signaling pathway.

Deletion of Gadd45a alone does not lead to increased lung tumors in mice, but coupled with an XPC deletion, it results in lung tumor progression

XPC, but not XPA, plays a significant role in the removal of oxidative DNA damage and preventing development of lung tumors