identification of PTHrP and ezrin as important regulators of lung cancer bone metastasis offers new mechanistic insights into the metastasis of lung cancer and provides potential targets for the prevention and treatment of lung cancer metastasis

high level expression contributes to non--small-cell lung cancer progression

Ezrin, E-cadherin and CD44V6 play an important role in the regulation of growth and meastasis of lung cancer.

Ezrin plays an important role in the tumorigenicity and metastasis of lung cancer cells.

Data shows that Ezrin and phosphorylated Ezrin were upregulated in non small cell lung carcinoma and correlated with the poor differentiation and late clinical stage suggesting there utilization as a novel prognostic biomarker of NSCLC.

High Ezrin expression is asasociated with lung adenocarcinoma.

These findings suggest that ezrin-EGFR interaction augments oncogenic functions of EGFR and that targeting ezrin may provide a potential novel approach to overcome erlotinib resistance in non-small cell lung cancer cells

[Increases in mRNA and Protein Levels of the Genes for the Actin-Binding Proteins Profilin, Fascin, and Ezrin Promote Metastasis in Non-Small Cell lung cancer].

in a mouse model of osteosarcoma ezrin was found to be necessary for metastasis; results showed that ezrin expression provided an early survival advantage for cancer cells that reached the lung