CCL2-expressing breast tumor cells engage CCR2(+) stromal cells of monocytic origin, including macrophages and preosteoclasts, to facilitate colonization in lung and bone

Single nucleotide polymorphism is associated with Non-Small Cell lung cancer in Tunisian patients

A polymorphism in MCP-1 may be correlated with the development of non-small cell clung cancer (NSCLC) in the Han nationality of Northern China. However, the polymorphism in CCR-2 is not involved in NSCLC.

HUMSCs expressing ISZ-sTRAIL might be an efficient therapeutic approach against lung cancer and MCP-1/CCR2 axis is essential for the tumor tropism of HUMSCs

The MCP-1/chemokine (C-C motif) ligand 2 (CCL2) expression mediated by the autocrine loop of PDGF-BB enhanced recruitment of macrophages through CCL2-CCR2 axis, which could ultimately increase expression of metastatic genes in lung cancer cells, finally promoting invasive potential of cancer cells.