Results identified TWIST1 loci showing significant differential DNA methylation levels between tumor and non-tumor lung and highly significant hypermethylation in adenocarcinoma.

analysis of twist expression in lung cancer provide clues to comprehensive understanding of the mechanisms, by which metastasis often develops in lung cancer

The suppression of TWIST1 in human lung cancer cells also induced cellular senescence

these results demonstrated for the first time that SIRT6 suppressed non-small cell lung cancer cells proliferation via down-regulation of Twist1 expression

High TWIST expression is associated with invasion and metastasis of hypoxic non-small cell lung cancer.

the results from the present study indicate that BaP enhances the epithelial-mesenchymal transition-associated migration of lung adenocarcinoma A549 cells by upregulating Twist1.

These studies identified harmine as a first-in-class TWIST1 inhibitor with marked anti-tumor activity in oncogene-driven non-small cell lung cancer (NSCLC)including EGFR mutant, KRAS mutant and MET altered NSCLC

MMP9 and TWIST1 were identified as more valuable biological targets for the early diagnosis and targeted therapy of lung cancer through Kaplan-Meier analysis of TCGA lung adenocarcinoma datasets.

TWIST1-miR-214 pathway in the control of migration and invasion of lung adenocarcinoma.

ilencing endogenous Ets1 by siRNA in mouse cell lines decreases Twist1 mRNA levels, decreases invasion, and increases cell growth. Ets1 and Twist1 are at the crossroad of several signaling pathways in cancer. Understanding their regulation may inform the development of therapies to impair lung tumor metastasis.

LINC01296/miR-598/Twist1 constitutes a positive feedback loop to promote the tumorigenesis of non-small cell lung cancer.

Study found that overexpression of Kruppel like factor 6 splice variant 1 (KLF6-SV1) promoted the expression of TWIST1, and up-regulation of TWIST1 expression might promote the infiltration of M2 macrophages by up-regulating CCL2, thereby promoting the involvement of epithelial-mesenchymal transition in the metastasis of lung cancer cells.

Low TWIST1 expression is associated with nonsmall cell lung cancer.

The study found that LUADT1 and Twist1 were upregulated in small cell lung cancer (SCLC), while miR-15a-3p was downregulated in SCLC.

lncRNA JPX/miR-33a-5p/Twist1 axis regulates tumorigenesis and metastasis of lung cancer by activating Wnt/beta-catenin signaling.

Relevance and prognostic ability of Twist, Slug and tumor spread through air spaces in lung adenocarcinoma.

The EMT transcription factor, Twist1, as a novel therapeutic target for pulmonary sarcomatoid carcinomas.

the suppression of Twist1 to physiological levels is sufficient to cause Kras mutant lung tumors to undergo senescence and lose their neoplastic features