results suggest that overexpression of tumor necrosis factor (TNF)-alpha or exogenous TNF-alpha limits pulmonary fibrosis

IL-10, but not TNF-alpha, TNF-beta, or IL-6 polymorphisms are associated with lung cancer

TNF-alpha polymorphism is associated with susceptibility and severity of non-small cell lung cancer

Study demonstrated a positive correlation between high TNF-alpha expression and favourable prognosis in non-small cell lung cancer in terms of overall survival.

TNFalpha can lead to the induction of NFkappaB signaling with a concomitant increase in spermidine/spermine N(1)-acetyltransferase (SSAT) expression in non-small cell lung cancer cells

These results suggest that IL-10, TNF-alpha and TGF-beta1 gene polymorphisms may affect host susceptibility to lung cancer and the outcome of the patients.

Ioniing radiation signaling in a lung tumor cell line is due to activation of NF-kappaB signaling by TNF-alpha.

CD40 signaling inhibits the proliferation of CD40-positive lung cancer cells through mTNF-alpha/TNFRI in vitro.

Decreased frequency of TNF-alpha-308 1/2 gene variant is associated with chronic obstructive pulmonary disease and lung cancer.

This study indicates that the TNF-alpha-308 and TNF-alpha-238 polymorphisms do not influence susceptibility to or severity of lung cancer in a Croatian population.

tumor necrosis factor alpha rs800629 was associated with anorexia in patients with non-small cell lung cancer; patients who were heterozygous and minor homozygous were less likely to suffer anorexia

Loss of TNFalpha is associated with non-small cell lung cancer.

Measurement of plasma TNF-alpha may not prove to be a good biomarker for predicting therapeutic efficacy at an early stage in non-small cell lung cancer.

An updated meta-analysis shows that the tumor necrosis factor-alpha -308A genotype is associated with an increased risk for development of chronic obstructive pulmonary disease in Asian but not Caucasian populations.

Allergic lung inflammation is mediated by soluble tumor necrosis factor (TNF) and attenuated by dominant-negative TNF biologics.

glycogen synthase kinase 3alpha/beta (GSK3alpha/beta) modulates tumor necrosis factor-a (TNF) induced increased lung vascular permeability

Single-base changes in the TNFA and IL6 alleles correlated with occurrance of lung cancers in the Han ethnic group.

TNF-alpha-238 polymorphism GG genotype and the G allele could have a promotional effect on the development of non-small cell lung cancer in the group of patients with a second primary cancer.

study indicates that the TNFalpha -308G > A and TNFalpha -238G > A would be associated with increased susceptibility to lung cancer but no significant association was found in TNFbeta + 252A > G polymorphism

Il-6, IL-17, TNF-alpha and VEGF levels were measured in exhaled breath condensate and serum of 15 patients with stage I-IIA non-small cell lung cancer.

The meta-analysis suggests that TNF-alpha gene 308G>A polymorphism is associated with an increased risk of lung cancer

SIRT1 is involved in B[a]P-induced transformation associated with activation of the TNF-alpha/beta-catenin axis and is as a potential therapeutic target for lung cancer

There was no association between the risk of non-small cell lung cancer and TNFalpha-308 polymorphism.

Bio informatics analysis of 982 lung cancer patients revealed that higher expression of TNF- alpha was associated with low risk of cancer progression while overexpression of IGF-1 was correlated with high risk. Collectively, these results reveal that the cytokines in the tumor microenvironment differentially modulate radiation therapy through a variety of signaling mechanisms.

ATM could be activated by lung cancer-associated TNF-alpha, up-regulate MMP-13 expression and thereby augment tumor metastasis

The cytotoxic activity of TNF-alpha may confer improved survival in non-small cell lung cancer patients.

tumour necrosis factor-alpha selectively reduces BMPR-II transcription and mediates post-translational BMPR-II cleavage via the sheddases, ADAM10 and ADAM17 in pulmonary artery smooth muscle cells.

NFkappaB and TNFalpha were identified as the most significantly up-regulated molecules in cisplatin-resistant and radioresistant lung cancer cells, respectively, compared with parental cells.

Study results demonstrated that TNFalpha decreased VASP expression by upregulating the expression of HIF1alpha to inhibit A549 cell proliferation and adhesion. Inhibition of transplanted tumor growth was associated with downregulation of VASP expression in nude mice. Bioinformatics analysis indicated that expression levels of VASP or HIF1alpha lead to differential outcomes of overall survival in lung carcinoma.

These findings support that there is a direct correlation between cytokines including interleukin-6, interleukin-8, interleukin-10, and tumor necrosis factor-alpha and cardiopulmonary bypass time, duration of operation, and intensive care unit stay.

Studies indicate that tumor necrosis factor (TNF)-308A/G polymorphism may contribute to individual suscepti-bility to chronic obstructive pulmonary disease (COPD) in Chinese population [Meta-Analysis].

Bleomycin led to increased expression and content of lung tumor necrosis factor (TNF)-alpha.

pulmonary-specific expression of tumor necrosis factor-alpha alters surfactant lipid metabolism.

Overexpression of tumor necrosis factor-alpha in the lungs alters immune response, matrix remodeling, and repair and maintenance pathways.

Umbelliprenin induced production of IFN-gamma and TNF-alpha, and reduced IL-10, IL-4, Foxp3 and TGF-beta in a mouse model of lung cancer.

the reduced tumor burden, increased numbers of NK cells in the lung, and increased hematopoiesis in Bcl11b(F/F)/CD4-Cre mice were all dependent on TNF-alpha.

PIN1 regulates pulmonary effects of endotoxin and tumor necrosis factor-alpha in mice.

Effects of tumor necrosis factor on viral replication and pulmonary inflammation during acute mouse adenovirus type 1 respiratory infection.