highly sensitive and specific immunomarker distinguishing between metastatic pulmonary and extrapulmonary adenocarcinoma in effusion cytology specimens

results show that TTF-1 is not expressed in normal and hyperplastic neuroendocrine(NE) cells or in carcinoids, but is expressed in high-grade NE proliferations and in lung adenocarcinomas

nuclear staining of TTF-1 was observed in two of six adenocarcinoma cell lines, none of seven small cell lung cancer cell lines, and none of three squamous lung cancer cell lines

-1 is expressed in pulmonary adenocarcinomas and SCLCs

nuclear galectin-3 and TTF-1 have roles in progression of non-small cell lung carcinoma

Our results suggest that an immunohistochemical panel consisting of TTF-1, CEA, CA-125, and OCT-4 is helpful in distinguishing most pulmonary and ovarian carcinomas with clear cell features.

Data suggest that TTF-1 gene missense mutation and synonymous mutation and the loss of TTF-1 protein and mRNA can be regarded as the important indices of molecular pathology of lung carcinoma.

TITF1 amplification and overexpression contribute to lung cancer cell proliferation rates and survival

TTF-1 nuclear expression is generally considered to be a relatively specific marker for lung and thyroid neoplasms the occasional immunoreactivity of ovarian carcinomas should be considered in the evaluation of neoplasms of unknown primary origin

As a molecular marker of detecting pleural micrometastasis, TTF-1 mRNA may be helpful to diagnose the cancer cells in pleural effusion of patients with lung cancer, especially with primary pulmonary adenocarcinoma.

study concludes that TTF1 amplification is a mechanism of high-level TTF1 expression in a subset of non-small cell lung carcinomas; when expressed at high levels, it is an independent biomarker of favourable prognosis in adenocarcinoma

Patients with no TTF-1 expression or TTF-1 expression and TTF-1 gene amplification tend to have a significantly worse prognosis than lung cancer patients with TTF-1 expression and no TTF-1 gene amplification

TTF 1 immunostaining has the potential to misguide a pathologist to conclude an ovarian or endometrial tumor being a lung metastasis

TTF1 expression defines a subgroup of patients with a favorable outcome and may be useful for prognostic stratification of patients with stage I lung adenocarcinoma.

Coactivation of the TTF-1 and NKX2-8 pathways identified a cluster of lung cancer patients with poor survival and were shown to exhibit resistance to cisplatin

Findings delineate potential links between TTF-1 and TGF-beta signaling in lung cancer progression through regulation of EMT and MET.

the percentage of lung carcinoma patients remaining unclassifiable by TTF-1/TP63 was twice that of the five-antibody (TRIM29, CEACAM5, SLC7A5, MUC1, and CK5/6) test

The combined use of napsin A and thyroid transcription factor-1 results in improved sensitivity and specificity for identifying pulmonary adenocarcinoma in primary lung tumors and in a metastatic setting.

TTF-1 mRNA-expressing CTCs might be a useful surrogate predictor of disease progression for non-small cell lung cancer (NSCLC) patients before clinical manifestations are apparent.

Although TTF-1 had a higher sensitivity, napsin-A was useful as a surrogate marker when encountering a poorly differentiated lung adenocarcinoma.

TTF-1 is useful in separating adenocarcinoma of the lung from non-pulmonary adenocarcinoma and malignant mesothelioma

co-expression with p63 in lung signet-ring cell carcinoma

Immunohistochemical staining using a combination of TTF-1, napsin A, p63, and CK5/6 allows subclassification of poorly differentiated non-small cell carcinomas on small lung biopsies in most cases.

Data show distinct significant correlations between TITF-1 protein expression and DNA copy gain with mutations in the lung adenocarcinoma-prevalent EGFR and KRAS oncogenes.

in combination with napsin A-positive immunostaining helps in differentiating primary lung adenocarcinoma

High TTF1 expression is associated with treatment response in non-small cell lung cancer.

Diagnostic utility of PAX8, TTF-1 and napsin A for discriminating metastatic carcinoma from primary adenocarcinoma of the lung.

Patients with lung adenocarcinoma without thyroid transcription factor 1 (TTF1) amplification tend to have better prognoses than those with TTF1 amplification in cases with positive TTF1 expressions.

High TTF-1 expression is associated with smoking and lung adenocarcinoma histology

expression levels of Nkx2-1 direct target genes identified in mouse development significantly correlate or anti-correlate to the levels of endogenous NKX2-1 in a dosage-dependent manner in multiple human lung tumor expression data sets.

Assessed gene amplifications and protein expression of NKX2-1 and FOXA1 in primary lung tumors (n = 554) and brain metastases (n = 68).

Positive NKX2-1 is associated with EGFR mutation in non-small-cell lung cancer.

summarizes the role of this transcription factor in the development, diagnosis, and prognosis of lung cancer in the hope of providing insights into the utility of Nkx2-1 as a novel biomarker of lung cancer.

suggest that LMO3 is a transcriptional signal transducer in NKX2-1-amplified lung adenocarcinomas

TTF1 expression in small-cell lung cancer is a cell lineage-specific phenomenon that involves the developing neural cell-specific homeoprotein BRN2.

data suggests that miR-365 suppresses the expression and therefore the oncogenic functions of NKX2-1 in lung cancer

TTF1 gene amplification is associated with response to therapy in lung adenocarcinomas.

A review of recent findings with special attention given to the role of NKX2-1 in lung development and carcinogenesis.

The differential expression of PAX8 and TTF-1 may prove useful in distinguishing between neuroendocrine carcinomas of pulmonary and thymic origin

24 cases each of pulmonary and esophageal adenocarcinoma were stained with TTF-1, napsin A, CDX2, 34betaE12, N-cadherin, and IMP3 in an attempt to find an optimal panel for differentiation. IMP3, CDX2, and N-cadherin are superior to either TTF-1 or napsin A.

The expression of GATA3 and TTF1 distinguishes metastatic mammary carcinoma from primary lung carcinoma.

in lung adenocarcinomas, KRAS mutations are prevalent in male smokers; EGFR mutations are associated with female sex, nonsmoking and lepidic and micropapillary growth; TTF1 has a role in survival; BRAF mutations have roles in survival

Both TTF-1 antibodies (clones 8G7G3/1 and SPT24) were useful in differentiating breast from pulmonary carcinomas. Nuclear expression of TTF-1 was detected in invasive breast cancers by 8G7G3/1, but not by SPT24.

TTF-1 is more sensitive than napsin for detection of lung sarcomatoid carcinoma, and no cases were positive for napsin but negative for TTF-1

Loss of TTF-1 is associated with low response to chemotherapy in non-small-cell lung cancer.

Overexpression of TTF1 was associated with lung cancer.

Evaluation of the microvessel density and the expression of MMP2 and MMP9 and TTF1 in the different subtypes of lung adenocarcinoma in Tunisia

In lung adenocarcinomas, positive and partial positive TTF-1 expression has a significant positive correlation with EGFR mutations(exon 19 and 21).

Primary non-small cell lung cancer tumors expressing TTF1 had lower fluorodeoxyglucose uptake than those that did not and this was a good prognostic indicator.

CK5/6, IMP3 and TTF1 immunostaining appears to be useful to improve the accuracy of cytological diagnoses between reactive mesothelial cells, metastatic adenocarcinoma of lung and non-lung origin in pleural effusion.

the combination of MUC5B and TTF-1 expression is useful for discriminating adenocarcinomas from squamous cell carcinomas, yielding prognostic significance in patients with lung adenocarcinoma.

Combined genomic and proteomic analyses demonstrated infrequent alteration of validated lung cancer targets but identified novel potential targets for TTF1-negative LUAD, including KEAP1/Nrf2 and DNA repair pathways

Authors suggest that NKX2-1 as a tumour suppressor or a tumour promoter in lung adenocarcinoma progression is dependent on p53 status.

TTF-1 had no prognostic value concerning OS, but may serve as a predictor for response to first line chemotherapy in small cell lung cancer.

Low expression levels of TTF-1 is associated with lung adenocarcinoma.

Aberrant expression of mir-365/TTF-1 may be involved in the tumor development in patients with non-small cell lung carcinoma.

Immunohistochemical comparison of two TTF-1 mAbs in atypical squamous lesions and sarcomatoid carcinoma of the lung, and pleural malignant mesothelioma suggest possibility for diagnostic errors.

it may be useful to combine NAPA and TTF-1 for increased sensitivity in lung cancer diagnostics. There is no substantial difference between monoclonal and polyclonal p40 and between different NAPA clones, whereas there is a difference between the TTF-1 clones 8G7G3/1 and SPT24

Suggest TTF-1 is a reliable marker in non-small cell lung carcinoma and can be used in differential diagnosis.

CK7, TTF-1 and napsin A are predominantly expressed in primary lung adenocarcinoma patients, with CDX-2 being inconsistently expressed.

EGFR knockdown led to upregulation of NKX2-1, suggesting a negative feedback loop. combined knockdown of NKX2-1 and EGFR in NCI-H1819 lung cancer cells reduced cell proliferation more than knockdown of either alone.

TTF-1 shows significant potential as a diagnostic marker to differentiate metastatic pulmonary from non-pulmonary adenocarcinomas in pleural or other effusions.

These findings describe recurrent NKX2-1 mutations in invasive mucinous adenocarcinomas of the lung and support NKX2-1 as a lineage-specific tumor suppressor gene in lung carcinogenesis.

Thyroid Transcription Factor 1 Alters the expression Profiles of Cytokine and Angiogenic Factors of lung cancer Cells.

Immunohistochemical detection of thyroid transcription factor 1, Napsin A, and P40 fragment of TP63 can be used in the subclassification of non-small cell lung carcinomas.

TTF1-expression had no significant impact on outcomes after irradiation of limited-disease small cell lung cancer.

TTF-1 immunoreactivity was seen in 19 pulmonary neuroendocrine carcinoma (PNEC) cases (95%) and 13 thymic (TNEC) cases (59.1%). TTF-1 positivity was associated with high sensitivity but low specificity for PNEC, and adding PAX8 negativity significantly increased the specificity. PAX8 positivity alone showed essentially 100% specificity and 86.4% sensitivity for TNEC.

Findings suggest that the novel non-transcriptional function of TTF-1 identified in this study may contribute to lung adenocarcinoma development by conferring tolerance to DNA RS, which is known to be inherently elicited by activation of various oncogenes.

Results suggest that the thyroid transcription factor 1 expression was independently associated with progression-free survival and overall survival in patients with advanced-stage non-squamous non-small cell lung cancer treated with pemetrexed-based chemotherapy.

Studied the prognostic relevance of thyroid transcription factor 1 (TTF1) copy number alterations (CNAs) and expression levels in non-small cell lung cancer; found TTF1 CNAs and expression high within tumors and between primary and metastatic tumors.

our findings show that miR-532-5p is a novel transcriptional target of TTF-1 that plays a tumor suppressive role by targeting KRAS and MKL2 in lung adenocarcinoma

Study shows that that NKX2-1 directly and positively regulates transcription of cyclin D1 in lung adenocarcinoma. Also, the expression of NKX2-1, but not cyclin D1, is significantly associated with metastatic incidence as an independent good prognostic factor of adenocarcinoma.

The genetic or epigenetic inactivation of NKX2-1/TTF-1 may play an essential role in the development and aberrant differentiation of non-TRU-type lung adenocarcinomas.

role of Thyroid Transcription Factor-1 and tumor differentiation in Resected lung Adenocarcinoma

NKX2-1 expression was upregulated in never-smokers , lung adenocarcinoma and patients with wild-type TP53. A negative correlation between NKX2-1 and miR-365 expression was found but there was no correlation between NKX2-1 and miR-33a expression. NKX2-1 expression impacts prognosis in early-stage non-small cell lung cancer patients, particularly in those with neither TP53 nor KRAS mutations.

TTF-1 (NKX2-1)-negative small cell lung cancers exhibited decreased neuroendocrine differentiation.

ASCL1/TTF-1/NFIB regulatory axis potentially contributes to the tumourigenesis of small cell lung cancer.

Data demonstrate that Selenbp1 is a direct target of Nkx2-1, which inhibits lung adenocarcinoma growth in vivo. Selenbp1 is an important suppressor of lung tumor growth that functions in a positive feedback loop with Nkx2-1, and whose loss is associated with worse patient outcome.

Low TITF1 expression is associated with lung adenocarcinoma.

FoxA1 and FoxA2 drive gastric differentiation and suppress squamous identity in NKX2-1-negative lung cancer.

Study suggests that TTF-1 is not a favorable prognostic factor in lung adenocarcinoma patients

This meta-analysis indicates a significant correlation between TTF-1 overexpression and EGFR mutations status in patients with Non-Small-Cell lung Carcinoma. [meta-analysis]

Comparative analysis of TTF-1 binding DNA regions in small-cell lung cancer and non-small-cell lung cancer.

The expressions of CK7 and TTF-1 (NKX2-1) are increased in patients with lung cancer complicated with SVCS, and are related to TNM stage, lymph node metastasis and differentiation degree.

[Analysis of Correlation between TTF-1 and Sensitivity to First-line Chemotherapy and Prognosis in Patients with Small Cell lung cancer].

The prognostic role of thyroid transcription factor-1 in lung adenocarcinoma.

Muc5b is a target gene of transcription factors (TTF-1, GATA-6) involved in lung differentiation programs during development and carcinogenesis. TTF-1 is a strong repressor of Muc5b.

A protein signature for Titf1/Nk x2-1, a known lineage survival oncogene in lung cancer, was found in plasmas of mouse models of lung adenocarcinoma.

Haploinsufficiency of Nkx2-1 in combination with oncogenic Kras(G12D) caused pulmonary tumors in mice that were phenotypically similar to human mucinous adenocarcinomas.

Molecular characterization of disseminated tumor cells indicates that downregulation of the transcription factor Nkx2-1 precedes lung adenocarcinoma dissemination.

Identify regulatory link between Nkx2-1, miR-200c, and the transcription factors Nfib and Myb, adding new players to the regulatory mechanisms driven by Nkx2-1 in lung epithelial cells that may have implications in lung development and tumorigenesis.