Over expression of TIMP-1 is associated with nonsmall cell lung carcinoma

TIMP-1 expression is increased only in carcinoma, but not in benign lung disease

expression of MMP-2 and TIMP-1 was found to be higher in lung cancer patients. Finally, we claim that determination of MMP-9 enzyme levels and expression of MMP-2 and -9 and TIMP-1 can be used as a marker in lung cancer.

Tamoxifen increased the transcriptional expression of TIMP-1 in SPC-A-1 lung adenocarcinoma cells.

High TIMP-1 is associated with non-small cell lung cancer.

Study shows that an increase of both exogenous and endogenous TIMP-1 led to the upregulation of miR-210 in a CD63/PI3K/AKT/HIF-1-dependent pathway in lung adenocarcinoma cells.

this study presents novel functions of TIMP-1 in promoting cancer metastasis and suggests TIMP-1 is a potential tissue biomarker for lymph invasion and distant metastasis of lung adenocarcinoma.

The CC genotype of TIMP1 rs4898 compared to the TT wild-type genotype may increase lung cancer risk in Taiwan and may serve as a marker for early detective and predictive purposes.

The tumor/stroma TIMP-1 intensity ratio in tissue is useful to predict tumor recurrence in non-small cell lung cancer.

TIMP-1 displays paradoxical effects on tumor progression suggesting that circulating TIMP-1 is efficient in suppressing lung colonization of melanoma cells.

Both MMP-9 and TIMP-1 are highly expressed in Lewis lung cancer, and are correlated to tumor invasion and metastasis.

Results suggest the possible application of IKK2 and Timp-1 inhibitors in treating lung cancer.

Spread of Lewis lung carcinoma cells from serum to the lungs was associated with increased serum content of TIMP-1 and TIMP-2.