Repression of type II TGF-beta receptor may act as significant determinant of lung adenocarcinoma invasiveness, an early step in tumor progression toward metastasis.

it was observed the progression of premalignant lung lesions toward carcinoma in situ is accompanied by a decrease in TBR II expression and apoptosis and an increase in the expression of Ki-67 and MC

Results suggest a mechanism for the downregulation of TbetaRII in lung cancer.

reduced TGF-beta-RII expression in human non-small cell lung cancer is a negative prognostic marker associated with more aggressive tumor behavior and worse clinical outcome

an association between TGF-betaRII-negative tumor and higher risk of metastasis to lungs and bones was verified.

TGF-beta1 gene C509T polymorphism might be associated with decreased risk of lung adenocarcinoma in Chinese females exposed to cooking oil fumes, but no association was observed TGFBR2 gene G875A polymorphism

TGFBR2 is regulated by an epigenetic auto-feedback regulation in non-small cell lung cancer.

This paper highlights that targeting the BMP and TGFbeta type I and type II receptors causes a downregulation of XIAP, TAK1, and Id1 leading to cell death of lung cancer cells.

High TGFBR2 expression is associated with small cell lung cancer.

MiR-9-5p promotes the proliferation, metastasis and invasion of non-small cell lung cancer cells by down-regulating TGFBR2 expression.

Low TGFBR2 expression is associated with non-small cell lung cancer metastasis.

the present study suggests an inhibitory role of lncRNA MBNL1-AS1 in CSC drug resistance of Non-small cell lung cancer (NSCLC) by upregulating miR-301b-3p-targeted TGFBR2.

Low level of TGFBR2 mRNA was associated with poor prognosis in patients with lung squamous cell carcinoma.The role of TGFBR2 signaling in the lung squamous cell carcinoma.

Neuropilin 1 modulates TGFbeta1induced epithelialmesenchymal transition in nonsmall cell lung cancer.

Deleting Tgfbr2 in a mouse model of mutant K-ras-induced lung carcinoma induced a highly invasive phenotype associated with lymph node metastasis and reduced survival.

The authors identify ELMO1 as a novel target of TGFbeta signaling and show that restoration of Tgfbr2 results in a complete block of ELMO1 in vivo. Knocking down Elmo1 impairs metastasis of carcinoma cells to the lung, thereby providing insights into the mechanisms of progression of Tgfbr2-deficient invasive transition zone squamous cell carcinoma.