High expression of TGF-beta1 may be involved in the incidence of lung cancer.

TGF-beta1 polymorphisms and their haplotypes is associated with adenocarcinoma and small cell carcinoma of the lung

we demonstrated that TGFbeta-1 enhanced cytotoxic (proapoptotic) action of doxorubicin towards cultured human lung carcinoma A549 cells.

study found no evidence of association of prostate cancer with five TGFB1 genetic polymorphisms and their haplotypic combinations in the Prostate, lung, Colorectal, and Ovarian Trial (PLCO)

These results suggest that IL-10, TNF-alpha and TGF-beta1 gene polymorphisms may affect host susceptibility to lung cancer and the outcome of the patients.

Temporal TGF-beta gene expression signature established in mouse primary hepatocytes successfully discriminated distinct subgroups of hepatocellular carcinoma and lung adenocarcinoma in humans.

TGFBI promoter methylation can be used as a potential prognostic marker for invasiveness and metastasis in prostate and lung cancer patients.

High TGFB1 serum levels are associated with locally advanced non-small cell lung cancer.

these studies support the notion that TGF-beta plays an important role in both bone-and lung metastases of basal-like breast cancer

TGF-beta1 29T>C genetic polymorphism is an independent factor associated with lymph node metastasis in adenocarcinoma of the lung.

In patients with a smoking status of <40 pack-years, the TGF-ss1 polymorphism, C-509T, was significantly associated with the prognosis of advanced non-small cell lung cancer, and the TT genotype was an independent prognostic factor for poor survival.

Estimation of plasma TGF-beta1 during the course of chemotherapy might not be a reliable biomarker for predicting therapeutic efficacy in non-small cell lung cancer

TGF-beta1 may promote lung adenocarcinoma invasion and metastasis via the mechanism of epithelial-to-mesenchymal transition

High transforming growth factor beta expression represents an important prognostic parameter for surgically resected non-small cell lung cancer.

findings suggest that miR-23a regulates TGF-beta-induced epithelial-mesenchymal transition by targeting E-cadherin in lung cancer cells

single-nucleotide polymorphism located on the transforming growth factor-beta-1 gene is associated with radiation pneumonitis in non-small-cell lung cancer.

no association between TGF-beta1 SNPs and radiation-induced lung toxicity in lung cancer European Caucasian patients

Single Nucleotide Polymorphisms in transforming growth factor beta gene is associated with brain metastasis in non-small-cell lung cancer

Genetic variations in TGFbeta1 is associated with radiation-induced thoracic toxicities in non-small-cell lung cancer.

SMAD2 and SMAD3 acetylatation by P300-CBP is mediated by TGFB1 in human lung cancer cells.

The TGF-beta1 C-509T CC genotype is associated with better overall survival in unresectable locally advanced non-small-cell lung cancer patients.

Using 3 different cancer cell lines whose tumorigenic properties are driven by TGF-beta signaling, we show that loss of Arkadia function, either by overexpression of dominant negative Arkadia or by siRNA-induced knockdown, inhibited lung colonization

High Transforming growth factor beta 1 is associated with bronchioloalveolar invasion in non-small cell lung cancer.

Human TGFb1 contribute to Staphylococcus epidermidis biofilm formation in lung cancer.

Together, these results suggest that p44/WDR77 expression causes the non-sensitivity of proliferating cells to TGFbeta signaling, thereby contributing to cellular proliferation during lung tumorigenesis.

Data indicate that concordant transforming growth factor-beta1 (TGFbeta-1) positive and EH-domain containing 1 (EHD1) negative as a strong favorable prognosis factor in non-small cell lung cancer (NSCLC).

High TGFB1 protein expression is associated with lymph node metastases in non-small cell lung cancers.

TGF-beta/NKX2.1/PIK3R3 axis is crucial in the TGF-beta-induced inhibition of cell proliferation, and the NKX2.1/PIK3R3 axis might become a target in TGF-beta receptor-repressed lung adenocarcinoma

FOSL2 facilitates TGF-beta1-induced migration by interaction with Smad3 in non-small cell lung cancer.FOSL2 positively regulates TGF-beta1 signalling .

This meta-analysis suggested that transforming growth factor-beta1 rs1800470 polymorphism was a risk factor of lung cancer.

VEGF, TGF-beta1, and endostatin significantly contribute to the poor cell differentiation in non-small cell lung cancer

MicroRNA-10a silencing reverses cisplatin resistance in the A549/cisplatin human lung cancer cell line via the transforming growth factor-beta/Smad2/STAT3/STAT5 pathway

this study is the first to demonstrate that HG treatment of A549 human lung epithelial cells promotes tumor cell invasion and increases metastasis-associated protein expression by up-regulating HO-1 expression via ROS or the TGF-b1/PI3K/Akt signaling

TGF-beta1 gene C509T polymorphism might be associated with decreased risk of lung adenocarcinoma in Chinese females exposed to cooking oil fumes, but no association was observed TGFBR2 gene G875A polymorphism

our findings suggest that Ski represses TGF-b-induced EMT and invasion by inhibiting SMAD-dependent signaling in non-small cell lung cancer

Data suggest that the transforming growth factor-b1 (TGFB1) rs1800469 polymorphism may be predictive biomarker for the risk of developing brain metastasis in non-small cell lung cancer patients.

TGF-beta1 induces epithelial-mesenchymal transition by the transactivation of epidermal growth factor signaling through Hyaluronan/CD44 in lung and breast cancer cells.

TGFbeta1-CXCR7 axis may be a prognostic marker and may provide novel targets for combinational therapies to be used in the treatment of advanced lung cancer in the future

Relationship between expression of TGF-beta1, Smad2, Smad4 and Prognosis of Patients with Resected Non-small Cell lung cancer

HoxB7 is associated with tumor metastasis in patients with lung adenocarcinoma and HoxB7 may be implicated in promoting the development of lung adenocarcinoma through activation of the TGF-beta/SMAD3 signaling.

overexpression of miR-93 in lung cancer cells promoted TGF-b-induced EMT through downregulation of NEDD4L. The analysis of publicly available gene expression array datasets indicates that low NEDD4L expression correlates with poor outcomes among patients with lung cancer, further supporting the oncogenic role of miR-93 in lung tumorigenesis and metastasis.

High TGFbeta expression is associated with Non-Small Cell lung cancer.

this study demonstrates that TGFbeta is a positive regulator of PAR-1 expression in A549 lung adenocarcinoma cells, which in turn increases the sensitivity of these cells to thrombin signalling

In this review, we discuss the effects of TGFb-driven transcription on all stages of tumour progression, with special focus on lung cancer. Since some TGFb target genes are specifically involved in promoting metastasis, we speculate that these genes might be good targets to block tumour progression without compromising the tumour suppressor effects of the TGFb pathway.

miR-29c overexpression could abrogate the tumor progression and inhibit the Sp1/TGF-beta expressions in vivo, indicating that miR-29c could be a tumor suppressor and repress the Sp1/TGF-beta axis-induced EMT in lung cancer.

IL10 and TGFb1 in systemic and tumor microcirculation are significantly associated with particular histological type of lung cancer, tumor size and degree of disease extent.

High TGFB expression is associated with increased lung adenocarcinoma.

MDA-9 upregulated active levels of known modulators of epithelial mesenchymal transformation, the small GTPases RhoA and Cdc42, via TGFbeta1, promoting lung metastasis of breast cancer cells.

This meta-analysis suggests that TGFbeta1 T+869C and C-509T polymorphisms may not contribute to lung cancer risk in the total population, while the T+869C polymorphism may increase the risk of lung cancer in the Caucasian population.

TGF-beta release from platelets is necessary for podoplanin-mediated tumor invasion and metastasis in lung cancer.

miR-9 was up-regulated and SOX7 was down-regulated in human non-small-cell lung cancer tissues and cell lines.

selective inhibition of SMAD3 or CCT6A efficiently suppresses TGF-beta-mediated metastasis. Findings provide a mechanism that directs TGF-beta signaling toward its prometastatic arm and may contribute to the development of therapeutic strategies targeting TGF-beta for non-small-cell lung carcinoma.

RCCD1 as a novel regulator of TGF-beta-induced epithelial mesenchymal transformation and cell migration in non-small lung carcinoma cells.

High RGFB1 expression is associated with non-small cell lung cancer invasion and metastasis.

MiR-128-3p overactivates the TGF-beta pathway in the non-small cell lung cancer cells.

Kruppel-like factor 4 overexpression inhibited transforming growth factor-beta1, extracellular signal-regulated protein kinase, C-jun N-terminal kinase, and nuclear factor-kappaB expression levels in non-small cell lung cancer cells.

Ectopic expression of KDM6A antagonized TGF-beta-induced epithelial-mesenchymal transition and cell migration of lung cancer cells through its demethylase activity.

identified trihydroxyphenolic compounds as potent blockers of TGF-beta1 responses (IC50 ~50 nM), Snail1 expression, and collagen deposition in vivo in models of pulmonary fibrosis and collagen-dependent lung cancer metastasis.

Suppression of TGF-beta1 enhances chemosensitivity of cisplatin-resistant lung cancer cells through the inhibition of drug-resistant proteins

PAI-1 and TGF-beta1 promote non-small cell lung cancer tumor cells and tumor-associated macrophages and might be valuable targets for cancer immunosuppression.

FPPS mediates TGF-beta1-induced lung cancer cell invasion and epithelial-to-mesenchymal transition via the RhoA/Rock1 pathway.

Taken together, these findings indicate TGFbeta1-induced down-regulation of microRNA-138 contributes to EMT in primary lung cancer cells, and suggest that miR-138 might serve as a potential therapeutic target.

This study identified a crucial role of autophagy as a potential positive regulator of TGFbeta1-induced EMT in Non-Small Cell lung cancer (NSCLC)cells and identifies inhibitors of autophagy as promising new drugs in antagonizing the role of EMT inducers, like TGFbeta1, in the clinical progression of NSCLC.

CTEN activated the expression of TGFB1, thereby prompting epithelial-mesenchymal transition in lung adenocarcinoma cancer cells.

TGFbeta1 induces epithelial to mesenchymal morphology transition in TGFbeta1 sensitive non-small cell lung cancer (NSCLC) lines but not in insensitive lines. TGFbeta1 not only increases the mesenchymal maker Vimentin expression, but also enhances NSCLC cell invasiveness. TGFbeta1 elevates both the expression level of cancer stem-like cell markers and anchorage-dependent colony formation ability in TGFbeta1 sensitive l...

experiments demonstrated that the MYEOV ceRNA sequestered miR-30c-2-3p from binding its targets TGFBR2 and USP15 mRNAs, which in turn leading to constitutive activation of TGF-beta signaling and tumor progression in Non-small cell lung cancer.

lncRNA GASL1 may inhibit tumor growth of non-small cell lung cancer cells by down-regulating TGF-beta1.

High TGFB1 expression is associated with non-small cell lung cancer metastasis.

LncRNA HAND2-AS1 inhibits non-small cell lung cancer migration, invasion and maintains cell stemness through the interactions with TGFB1.

angiogenesis of lung cancer may be related to the interaction of SPARC, TGFbeta1 and Endoglin

High TGFB1 expression is associated with Metastasis in Non-Small Cell lung cancer.

lncRNA CASC11 promotes TGF-beta1, increases cancer cell stemness and predicts postoperative survival in small cell lung cancer.

lung cancer patients carrying the TGFB1 rs11466353 GG genotype were found to be associated with a lower risk of late grade 2 radiation-induced esophageal toxicity (RIET) compared with those with the TT/TG genotypes. Patients receiving a high (>60Gy) radiation dose who presented the rs11466353 GG genotype had a significantly lower RIET incidence.

The high expression of TGF-beta could significantly predict poor prognosis in non-small cell lung cancer patients. [systematic review and meta-analysis]

hsa-miR21 and TGF-beta1 are involved in autocrine and paracrine circuits that regulate the epithelial-mesenchymal transition status of lung cancer cells.

High Stromal TGFBI in lung cancer and Intratumoral CD8-Positive T Cells were Associated with Poor Prognosis and Therapeutic Resistance to Immune Checkpoint Inhibitors.

The TGF-beta1 T + 869C (rs1982073) and C-509T (rs1800469) polymorphisms are not implicated in lung cancer susceptibility in the overall population. However, our analysis indicated that the C-509T (rs1800469) polymorphism decreases the risk of lung cancer in patients with nonsmall-cell lung cancer

DLC1 tumor suppressor regulates CD105 expression on human non-small cell lung carcinoma cells through inhibiting TGFB1 signaling.

Fucoidan increased the sensitivity to gefitinib in lung cancer cells correlates with reduction of TGFbeta-mediated Slug expression.

LncRNA WT1-AS over-expression inhibits non-small cell lung cancer cell stemness by down-regulating TGF-beta1.

Prognostic value of the TGFbeta1 rs4803455 single nucleotide polymorphism in small cell lung cancer.

TGF-beta promote epithelial-mesenchymal transition via NF-kappaB/NOX4/ROS signal pathway in lung cancer cells.

TGF-beta can promote the formation of lung metastases while impairing Neu-induced tumor growth and suggest that extravasation of breast cancer cells from pulmonary vessels is a point of action of TGF-beta in the metastatic process.

in vivo function of TGF-beta signaling specifically in airway epithelium during the development of allergic asthma and lung cancer

activation of TLR4 signaling pathway in lung cancer cells may be involved in tumor escape and progression by promoting the expression of TGF-beta1 and IL-10 and tumor cells migration

Umbelliprenin induced production of IFN-gamma and TNF-alpha, and reduced IL-10, IL-4, Foxp3 and TGF-beta in a mouse model of lung cancer.

Downregulation of TGF-beta1 and integrin beta3 impairs lymph node metastasis in a mouse model of non-small-cell lung cancer.