TfR1 expression is attenuated in a cell-density-dependent manner in human lung cancer H1299 cells and in murine B6 fibroblasts as the result of a marked decrease in mRNA content.

There is a correlation between high expression of TFR1 on tumor cells from males with non-small-cell lung cancer that is associated with higher values of inflammation parameters (alpha-1 globulin and alpha-2 globulin) and lower erythrocyte sedimentation rate.

EGFR regulates iron homeostasis to promote non-small cell lung cancer growth through redistribution of transferrin receptor 1.

Our data provide evidence that blocking TfR could significantly inhibit lung adenocarcinoma (LAC) proliferation by targeting the oncogene KRAS; therefore, TfR may be a therapeutic target for LAC. In addition, our results suggest a new method for blocking the signal from the oncogene KRAS by targeting TfR in LAC.