effect of human telomerase reverse transcriptase (hTERT) gene antisense oligodeoxynucleotide (ASODN) on telomerase activity and apoptosis in lung cancer cell A549 line

The higher expression level of hTERT mRNA is associated with shorter survival in patients with stage I non-small cell lung cancer.

telomerase hTERT gene expression in broncho-alveolar lavage fluid of patients with lung carcinomas

The association between RARbeta and hTERT expression suggests that RARbeta expression may be an indicator of increased risk of lung cancer in heavy smokers.

There were three splicing variants in NASG 3'UTR. Its abnormal expression may be an important molecular event in NPC and lung cancer.

MNS16A is a polymorphic minisatellite (VNTR) in downstream region of human telomerase gene locus and functionally associated with promoter activity of an antisense RNA transcript, thus may have a role in lung tumorigenesis.

Results indicate that telomerase is repressed in most lung carcinoids and that hTERT transcription and alternative splicing play a role in such a negative regulation.

Inhibition of histone deacetylation selectively regulates the transcriptional derepression of telomerase catalytic subunit in normal lung fibroblast cells compared to lung tumor cells.

An increase in telomerase activity in normal bronchial epithelium might extend the lifespan of cells at risk for malignant transformation, and thus contribute to lung carcinogenesis.

hTERT gene amplification and mRNA overexpression is associated with non-small-cell lung cancer

Ten different alternatively spliced sites were detected in hTERT and the majority of hTERT cDNA clones from normal and tumour lung and colon tissues encoded truncated proteins ending close after exon 2 or 6.

The expression of hTERT mRNA may play a role in pathogenesis in pulmonary neuroendocrine tumors, and be a useful tool for differential diagnosis between typical carcinoids and large cell neuroendocrine carcinoma.

activating enhancer-binding protein-2beta (AP-2beta) as a novel transcription factor that specifically binds to and activates the hTERT promoter in human lung cancer cells.

Telomerase activity in aspirates collected through transthoracic fine-needle biopsy aspirates of primary peripheral non-small cell lung cancer could be a helpful independent prognostic factor

The susceptibility region contains two genes, TERT and CLPTM1L, suggesting that one or both may have a role in lung cancer etiology.

Transcriptional activation of hTERT by E6 oncoprotein is required for HPV-16/18-infected lung tumorigenesis.

Reduced hTERT mRNA expression may play an important role in the occurrence of lung cancer. The expression of hTERT mRNA and deletion of Mad1 protein are closely related to pathogenesis of lung cancer.

Increased human telomerase reverse transcriptase mRNA expression but not telomerase activity is associated with non-small cell lung cancer

Patients with lung cancer, and especially those with nonsmall cell lung cancer, had significantly higher percentages of cells with amplification of TERC than did patients with nonmalignant disease

TERT-CLPTM1L variants may influence the risk of lung cancer.

individuals susceptible to lung adenocarcinoma can be defined by combined genotypes of HLA-DQA1 and TERT.

High TERT activity is associated with non-small cell lung cancer.

The functional of hTERT variant genotype (MNS16A-SS genotype) may be a marker for poorer survival in early-stage non-small cell lung cancer.

Detection of hTERT mRNA expression in tumour-distant normal lung tissue may indicate an increased risk of progressive disease.

MNS16A VNTR polymorphism in the TERT gene has dual, conflicting roles in lung carcinogenesis.

High telomerase reverse transcriptase is associated with non-small cell lung cancer.

the lung cancer susceptibility locus Tert-Clptm1l on chromosome 5p15.33 increases the risk for bronchial obstruction and emphysema.

Single-nucleotide polymorphisms in TERT is associated with lung cancer.

For rs2736100, the G variant and the GG genotype were more frequent, whereas the TT genotype was less frequent in patients with lung adenocarcinoma than in controls.

Telomerase activity may serve as a reliable and effective molecular marker to assist the evaluation of histological subtype and differentiation of lung carcinomas.

Single-nucleotide polymorphism in the TERT gene is associated with lung cancer susceptibility.

results suggest that genetic variants in the TERT-CLPTM1L gene may predispose individuals to be susceptible to lung cancer, particularly non-small cell lung cancer, in the Chinese population

The 5p15.33 region containing telomerase reverse transcriptase gene (TERT) and cleft lip and palate transmembrane protein 1-like (CLPTM1L) gene showed significant association with lung cancer in Han Chinese.

Our results reiterate that genetic variants of TERT and CLPTM1L contribute to lung cancer susceptibility in Chinese population.

Single-nucleotide polymorphisms of rs2736100 in the HTERT gene is associated with lung cancer risk in African Americans.

Longer telomere length in peripheral white blood cells is associated with risk of lung cancer and the rs2736100 (CLPTM1L-TERT) polymorphism.

Genetic variants in TERT and CLPTM1L may affect the susceptibility of lung cancer

Telomerase activity in bronchial aspirates is a promising diagnostic marker for lung cancer and inflammation detection.

Polymorphism in TERT gene is associated with lung cancer.

The present study suggests that combination of the inhibitors of telomerase and tankyrase can be used as a strategy for the treatment of lung cancer in humans.

h-TERT mRNA levels in the patients with idiopathic pulmonary fibrosis were higher compared with those in the controls (p=0.03) and patients with non-small cell lung cancer (p=0.007).

Results show that CCCTC-binding factor (CTCF) plays an important role in maintaining telomerase reverse transcriptase catalytic subunit (TERT) expression in a subset of lung cancer cell lines may be due to CTCF-dependent enhancer-promoter interactions.

TERT genetic polymorphism rs2736100 was associated with lung cancer

the role of TERT-CLPTM1L variants in the etiology of esophageal squamous cell carcinoma and lung cancer

TERT rs2736100 polymorphism is a risk factor associated with increased lung cancer susceptibility, particularly for lung adenocarcinoma

TERT rs2736100T/G polymorphism modulates IL-6 expression and may play a unique role in lung adenocarcinoma.

meta-analysis suggested that TERT rs2736100 polymorphism was a risk factor for lung cancer

data provide further evidence supporting a role for genetic susceptibility of TERT rs2736100 in the development of lung cancer

TERT rs2736098 polymorphism is associated with lung cancer.

The TERT-rs2736098 T allele was associated with increased lung cancer risk both in adenocarcinoma and squamous cell carcinoma in Chinese males.

diosgenin prevents telomerase activity by down regulation of the hTERT gene expression in A549 lung cancer cell line

TERT polymorphism (rs2736100) might be a genetic susceptibility factor for lung cancer in non-smoking females in China.

Polymorphisms in the TERT gene contribute to the risk for lung cancer in the Chinese Han population.

These results demonstrate that RFPL3 is an important cellular factor which promotes lung cancer growth by activating hTERT expression

These data suggested that Ets-2, a genuine cancer-specific transcription factor, is actively involved in EGFR kinase-induced hTERT overexpression pathway in lung cancer cells.

TERT rs2735940 polymorphism was significantly associated with cancer risk, especially lung cancer.

study found frequencies of TERT promoter mutation among squamous cell carcinomas(SCC)of different sits are heterogenous: ~70% in skin SCC and urothelial carcinoma with squamous differentiation, 16.67% in head and neck SCC, and 0% in lung and cervix SCC

rs2736100 on TERT-CLPTM1L indicates a poor prognosis for lung cancer in the Chinese Han population.

The TERT SNP rs2736109 showed significant correlation with the progression-free survival in platinum treated non-small cell lung cancer patients.

This meta-analysis suggests that the TERT genetic polymorphism rs2853676 is associated with increased risk of glioma, lung adenocarcinoma and ovarian cancer among Caucasians.

Our study suggests that telomerase (TERT)and telomere function may be essential for carcinogenesis of EGFRmut(+) non-small cell lung cancer

RFPL3 and CBP have roles in upregulating hTERT activity and promoting lung cancer growth

The results suggest that a common functional promoter polymorphism, TERT rs2853669, may influence both telomere length and lung cancer risk in the Korean population.

copy number variations in TERT gene is associated with lung adenocarcinoma.

pTERTm are a moderately prevalent genetic event in non-small-cell lung cancer. The current meta-analysis indicates that pTERTm is associated with patient age, gender and distant metastasis and may serve as an adverse prognostic factor in cancers.

Data suggest that the Kruppel-like factor 4 (KLF4) /telomerase reverse transcriptase (hTERT)/MAPK pathway is a potential new therapeutic target for lung cancer.

The results of current study indicated that G allele of the rs2736100 and A allele of the rs2736098 of TERT were associated with increased Non-Small Cell lung cancers Risk.

Snail1 may be a co-factor of TERT enhancer rs2853677 for predicting lung adenocarcinoma susceptibility and prognosis

PTEN downregulates the PI3K/AKT/hTERT pathway, thereby suppressing the growth of lung adenocarcinoma cells.

NSCLC patients with higher expression level of TERT mRNA in lung tumor tissues had a longer MST and decreased death risk than those with low expression level of TERT mRNA

Variant in TERT gene is associated with lung cancer susceptibility.

E6 upregulation of hTERT by downregulated LKB1 and upregulated SP1 in lung cancer cells. These results indicated that E6 played a predominant role in the regulation of telomerase activation and may be a valuable therapeutic targets for HPV-related cancer.

that the rs401681 polymorphism in the TERT-CLPTM1L locus contributes to lung carcinogenesis only in patients harboring an EGFR mutation

No association between TERT expression in non-small-cell lung cancer specimens and survival rates was found.A significant difference in TERT expression between two types of histopathological patterns adenocarcinoma and squamous cell carcinoma was detected in the non-small-cell lung cancer specimens.

We demonstrated that PNA (Peptide Nucleic Acid )clamping has a higher sensitivity than DS for detecting oncogenic alterations in NSCLC ( non-small cell lung cancer ). Our findings suggest that PNA clamping is a more useful method for clinical practice.

EGF significantly upregulated RFPL3 and hTERT protein levels in the nonsmall cell lung cancer cells. RFPL3 and hTERT proteins upregulation by EGF were attenuated by pretreatment with AG1478 and erlotinib. EGF promoted proliferation and inhibited apoptosis; PD98059 decreased RFPL3 and hTERT protein expression; and RFPL3 overexpression increased the expression of hTERT and related MEKpathway proteins

rs401681 and rs402710 single nucleotide polymorphism of CLPTM1L confer lung cancer risk by regulating TERT expression instead of CLPTM1L.

NOVA1 has a role in regulating hTERT splicing and cell growth in non-small cell lung cancer

Results found that rs7726159, rs10054203, rs2736107, and rs2853677 in TERT gene exhibited significant associations with the risk of lung cancer, particularly for adenocarcinoma. Besides, the risk allele of rs7726159 and rs10054203 were associated with long telomeres. rs7726159 regulated telomere length through altering MYC binding and affecting TERT transcription, thus accelerating lung cancer development.

These results suggested that rs2853677 of TERT signifies association in multiple cancers and suggests that it can become potential marker for diagnosis of non-small cell lung cancer and leukemia.

The rs2853669 T/C allele was significantly associated with lower TERT mRNA expression and shorter relative telomere length in patients without EGFR mutation resulting in non-small cell lung cancer.

The rs10069690 was significantly associated with an increased risk of cancer overall. Stratification analysis revealed an increased cancer risk in subgroups of breast cancer, ovarian cancer, lung cancer, thyroid cancer, and renal cell carcinoma.

Both TERT-rs33963617 and CLPTM1L-rs77518573 conferred reduced risk for Non small cell lung cancer in Chinese Han population.

The Prognostic Significance of TERT Locus Polymorphism (rs36115365) in Surgically Resected Non-Small Cell lung cancer.

Results indicate that, in rat lung epithelial cells, in vitro transformation and acquisition of tumorigenic properties can occur even if telomere length is still decreasing and telomerase activity remains downregulated.