High miR-411 expression is associated with aggressive lung adenocarcinoma.

our study revealed miR-411 promoted cell proliferation of lung cancer by targeting tumor suppressor gene FOXO1 and miR-411 might be a potential target for lung cancer therapy.

Study shows that miR-411-5p edited in position 5 was significantly dysregulated in tissues as well as in exosomes of Non-Small Cell lung cancer (NSCLC) patients, suggesting a potential targetome shift relevant to lung cancer biology.

Overexpression of MiR-411 results in the decrease of the proliferation of non-small cell lung cancer cells.

miR-411-5p/3p are required for Non small cell lung carcinoma development by suppressing SPRY4 and TXNIP; thus, the miR-411-SPRY4-AKT axis might act as a promising target for lung cancer therapy clinically.