Links to all GeneRIF Items | 688 |
PubMed (Gene Name) | Literature evidence |
|---|---|
| 20639455 (KLF5) | while KLF5 is not required for oncogenic mutant K-Ras-induced lung tumorigenesis, KLF5 regulation of ABCG2 expression may be important for chemotherapeutic resistance and patient survival. |
| 24401325 (KLF5) | KLF5/Sox4 regulatory signaling play an important role in lung tumorigenesis, which might represent novel therapeutic targets to manage lung carcinoma. |
| 25051115 (KLF5) | Using small interfering RNA (siRNA) targeting KLF5 or HIF-1alpha, study demonstrated that KLF5 or HIF-1alpha knockdown inhibited hypoxia-induced cell survival and promoted cell apoptosis by actively downregulating cyclin B1, survivin and upregulating caspase-3 in lung cancer cells. |