The findings point to a role of EMMPRIN for the progression of adenocarcinoma of the lung that is unrelated to its function as inducer of MMPs.

MIF and CD147 may play important roles in invasion and metastasis in non-small cell lung cancer.

Sp1 is essential for regulating the CD147 gene expression in human lung cancer.

EMMPRIN regulates the canonical Wnt/beta-catenin signaling pathway, a potential role in accelerating lung tumorigenesis.

High CD147 expression is associated with non-small cell lung cancer and chemotherapy resistance.

CD147 and MMP-2 expression is correlated with the invasion and metastasis of squamous cell carcinoma and adenocarcinoma of the lungs

Overexpressions of CD147 is associated with stage T1 pulmonary adenocarcinoma.

HAb18G protein expression is associated with non-small cell carcinoma lung tumor progression and prognosis.

Data suggest that CD147 overexpression upregulated the protein expression of MMP-9, and strengthened the proliferation and invasive ability of lung adenocarcinoma cells.

Cellular localization of CD147 should be considered in the analysis of clinicopathological characteristics and prognostic factors in non-small cell lung cancer.

HAb18G overexpression plays an important role in progression of non-small lung cancer.

High CD147 expression is associated with non-small cell lung cancer.

Disruption of BASIGIN decreases lactic acid export and sensitizes non-small cell lung cancer to biguanides independently of the LKB1 status.

findings indicate that Rab22a enhances recycling of CD147, which is required for lung cancer cell migration and invasion,and targeting CD147 recycling may be a rational strategy for lung cancer therapy

Overexpression of EMMPRIN was associated with lymphatic metastasis and advanced stage of non-small cell lung cancer

BSG expression is indicative of a poor prognosis in pulmonary adenocarcinoma

Higher CD147 expression was found in EGFR-TKI-sensitive non-small cell lung cancer (NSCLC) cell lines than in relatively resistant NSCLC cell lines.

Study verified the target action association between TCSF and miR146a5p with high throughput data analysis and experimental results in nonsmall cell lung cancer (NSCLC). Protein level of TCSF in cancerous lung tissues was upregulated in NSCLC tissues. In vitro experiment in A549 cell line revealed that miR-146a-5p had a role in cell viability, proliferation and apoptosis by regulating the target gene TCSF.

The Combination of CD147 and MMP-9 Serum Levels Is Identified as Novel Chemotherapy Response Markers of Advanced Non-Small-Cell lung cancer.

Taken together, these results indicate that CD147 promotes lung cancer-induced osteoclastogenesis by modulating IL-8 secretion, and suggest that CD147 is a potential therapeutic target for cancer-associated bone resorption in lung cancer patients.