Perimembrane Aurora-A status was a significant factor to predict a poor prognosis in correction with enhanced proliferative activity in non-small cell lung cancer.

This study evaluated the role of genetic polymorphisms of Aurora-A gene in the lung cancer in the Turkish population.

AURA is a novel target of transcriptional regulation by histone deacetylase inhibitors in non-small cell lung cancer.

These results indicate that in non small cell lung cancer AURKA over-expression is restricted to specific subtypes and poorly differentiated tumors.

The interplay between EGFR and AURKA provides an explanation for the difference in EGF dependency between EGFR-WT and EGFR-mutant cells and may provide a new therapeutic strategy for lung cancer patients carrying EGFR mutations.

Data indicate the antitumor and radiosensitizing activity of daurinol in lung cancer cells through the inhibition of aurora kinase A/B (AURKA and AURKB).

Aurora kinases are important KRAS targets in lung cancer.

Results confirmed that AURKA is highly expressed in lung adenocarcinoma tissues and human lung adenocarcinoma cell lines. Its knockdown in human lung adenocarcinoma could inhibit cell growth and proliferation in vitro providing evidence for its important roles in the proliferation of human lung adenocarcinoma cells.

Study suggests AURKA and TPX2 as potential stratification markers for taxane-based radiochemotherapy. lung adenocarcinoma cohort, high expression levels of AURKA and TPX2 were associated with specifically improved overall survival upon taxane-based radiochemotherapy.

Our findings showed novel regulatory mechanisms of p53 in regulating Aurora-A gene expression in non-small cell lung carcinoma cells.

Results identified AURKA to be significantly upregulated in the lung squamous cell carcinoma tissues of smoking patients and may play an important role in diagnosis and prognosis.

LKB1 undergoes AURKA-mediated phosphorylation, which largely compromises the LKB1/AMPK signaling axis, in turn leading to the elevation of non-small cell lung cancer cell proliferation, invasion and migration.

Study revealed that Aurora A expression was significantly higher in docetaxelresistant lung adenocarcinoma (LAD) cells than in parental cells. miR8853p could target Aurora A directly acting as a chemosensitizer to docetaxel in human LAD cells.

Study indicated that AURKA, CDC20 and TPX2 are over-expressed in smoking related lung adenocarcinoma tissues and their higher mRNA expression levels have a worse prognosis.

High AURORA-A expression is associated with radio-resistance of docetaxel-resistant lung Adenocarcinoma.

Identification of lung adenocarcinoma biomarkers based on bioinformatic analysis and human samples.

Establishment of a CALU, AURKA, and MCM2 gene panel for discrimination of metastasis from primary colon and lung cancers.

Loss of Aurora Kinase Signaling Allows lung cancer Cells to Adopt Endoreplication and Form Polyploid Giant cancer Cells That Resist Antimitotic Drugs.