Links to all GeneRIF Items | 6732 |
PubMed (Gene Name) | Literature evidence |
|---|---|
| 25774502 (SRPK1) | SRPK1 was highly expressed in basal breast cancer. High SRPK1 expression correlated with poor breast cancer disease outcome and preferential metastasis to the lungs and brain. |
| 25774502 (Srpk1) | In 2 independent murine models of breast tumor metastasis, stable shRNA-based SRPK1 knockdown suppressed metastasis to distant organs, including lung, liver, and spleen, and inhibited focal adhesion reorganization. |