Data suggest that SOX9 is a new hallmark of lung adenocarcinoma, in which SOX9 might contribute to gain of tumor growth potential, possibly acting through affecting the expression of cell cycle regulators p21 and CDK4.

SOX9 may serve as a novel and prognostic marker fornon-small cell lung cancer ( NSCLC), and play a role during the development and progression of the disease.

Results identify a new functional role for a Notch1-Sox9 signaling axis in lung ADC that may explain the correlation of Sox9 with tumor progression, higher tumor grade, and poor lung cancer survival.

miR-124 functions as a tumor suppressor in lung adenocarcinoma by directly targeting SOX9.

Our data proved that RMRP acted as an oncogene LncRNA to promote the expression of KRAS, FMNL2 and SOX9 by inhibiting miR-206 expression in lung cancer. These data suggested that RMRP might serve as a therapeutic target in lung adenocarcinoma

MiR-592 functions as tumor suppressor in non-small cell lung cancer by suppressing the activity of SOX9.

Knockdown of SOX9 expression by RNA interference reduces cell proliferation and induces apoptosis of lung cancer cells, which was consistent with the results obtained from silencing the expression of LASP-1 in NCIH1650 cells.

miR-185 inversely regulates SOX9 expression in non-small cell lung cancer.

Results find SOX9 highly expressed in non-small cell lung cancer (NSCLC) tissues, and positively correlates with that of MALAT1. Moreover, SOX9 protein expression was higher in NSCLC tissues expressing highly especially MALAT1 mRNA.

SOX9 expression was elevated in human lung carcinoma cells.

FOXA1 and SOX9 are up-regulated in lung carcinoma. SOX9 is a transcriptional regulator of FOXA1. SOX9 dependent FOXA1 expression promotes tumorigenesis in lung carcinoma.

aarF domain containing kinase 5 gene promotes invasion and migration of lung cancer cells through ADCK5-SOX9-PTTG1 pathway.