mutation of SOX4 gene in the different tumor tissues with pathological stages and types of non-small cell lung cancer (NSCLC)

In lung cancer, SOX4 is overexpressed due to gene amplification and provide evidence of oncogenic properties of SOX4.

KLF5/Sox4 regulatory signaling play an important role in lung tumorigenesis, which might represent novel therapeutic targets to manage lung carcinoma.

SOX4 plays an important role on non-small cell lung cancer (NSCLC) progression and prognosis and may serve as a convictive prognostic biomarker for NSCLC patients.

High SOX4 expression is associated with Non-Small Cell lung cancer.

our data indicated that miR-212 functions as a tumor-suppressor gene by regulating EMT and metastasis of non-small cell lung cancer (NSCLC)by targeting SOX4 signaling, and may represent a novel potential therapeutic target and prognostic marker for NSCLC.

CCAT1/miR-130a-3p axis enhanced cisplatin resistance of non-small-cell lung cancer (NSCLC) cells by targeting SOX4, providing potential targets to overcome cisplatin resistance and improve efficacy of chemotherapy for patients with NSCLC

The upregulation of SOX4 impaired the inhibitory effect of miR-204 on lung adenocarcinoma metastasis.

this study provides evidence for the existence of a p53/miR-30a-5p/SOX4 feedback loop, which likely plays a key role in the regulation of proliferation, apoptosis, and migration in non-small-cell lung cancer, highlighting a new therapeutic target.

miR-363-3p inhibits migration, invasion, and epithelial-mesenchymal transition by targeting NEDD9 and SOX4 in non-small-cell lung cancer.

Long non-coding RNA OR3A4 is associated with poor prognosis of human non-small cell lung cancer and regulates cell proliferation via up-regulating SOX4.

MicroRNA-138 targets SOX4 to regulate the proliferation and metastasis of human lung cancer cells.