UCA1 may induce non-T790M acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors by activating the AKT/mTOR pathway and epithelial-mesenchymal transition in EGFR-mutant non-small cell lung cancer

Conclude that UCA1 functions as an oncogene in non-small cell lung carcinoma, acting mechanistically by upregulating ERBB4 in part through 'spongeing' miR-193a-3p.

lncRNA UCA1 was highly expressed in human lung cancer cells.

High UCA1 expression is associated with lung metastasis in gastric cancer.

UCA1 down-regulation inhibited cell proliferation and migration in both SKMES-1 and H520 lung cancer cells. This study demonstrated that UCA1 exerts oncogenes activity in lung cancer, acting mechanistically by upregulating HMGB1 expression through 'sponging' miR-193a.

lncRNA UCA1 suppression inhibits migration and invasion of lung cancers cells at least in part via regulation MAPK1 expression.

Long non-coding RNA UCA1 inhibits MAPK1 expression by miR-143 up-regulation, modulating the proliferation, migration and invasion of human lung cancer cells.

Deregulation of UCA1 expression may be involved in the development of chemoresistance to cisplatin in the treatment of non-small-cell lung cancer via regulating the signaling pathway of microRNA-495/NRF2.

LncRNA WT1-AS downregulates lncRNA UCA1 to suppress non-small cell lung cancer and predicts poor survival.