expression of the mature BMP-2 protein is disregulated in the majority of NSCLC. BMP-2 enhancement of tumor cell migration and invasion, as well as stimulating tumor growth in vivo, suggests it has important biological activity in lung carcinomas.

Forced expression of BMP-2 in A549 cells significantly enhanced tumor growth in the lungs following intravenous injection but not of subcutaneous tumors

level of expression is associated with lung cancer

Elevated BMP2 synthesis is associated with increased malignancy in mouse models of lung cancer and poor lung cancer patient prognosis

High serum BMP2 is associated with metastais in non-small-cell lung cancer.

novel evidence that inhibition of BMP-2 or BMP-2-mediated MAPK/Runx2/Snail signaling is an attractive therapeutic target for osteolytic bone metastases in lung cancer patients.

Serum BMP-2 up-regulation is associated with advanced non-small cell lung cancer.

BMP-2 silencing can significantly inhibit non-small lung cancer cell proliferation and migration.

BMP2 expression in human lung fibroblasts has a role in lung adenocarcinomas

Bmp2 is a downstream target of the calcineurin/NFAT pathway in lung endothelium, potently inhibiting cancer cell growth by stimulating differentiation.

BMP2 signalling activation enhances bone metastases of non-small cell lung cancer.