Bmi-1 expression in non-small cell lung cancer (NSCLC) in respect to clinicopathological features and therapeutic outcomes

High BMI1 is associated with lung adenocarcinoma.

Increase of BMI1 is associated with lung adenocarcinoma.

WWOX was identified as a Bmi1 target in small cell lung cancer cells

Bmi-1 may be associated with the epithelial-mesenchymal transition in lung squamous cell carcinoma

Bmi-1 regulates key pathways involved in the metastasis of lung adenocarcinoma cells.

Bmi1 and FoxF1 may cooperate with hedgehog signaling in non-small-cell lung carcinogenesis.

Bmi-1 was a significant prognostic factor of poor overall survival in lung adenocarcinoma patients.

Data show that C/EBPalpha is a tumor suppressor in lung cancer and that BMI1 is required for the oncogenic process downstream of C/EBPalpha loss.

Low BMI-1 expression Correlates with pulmonary Squamous Cell Carcinoma.

Authors found that compared with control subjects, BMI1 mRNA expression in whole blood of advanced NSCLC patients was decreased. Similarly, authors observed decreased BMI1 mRNA expression in primary tumors compared to normal lungs from operable NSCLC patients.

Meta-analysis suggested that Bmi-1 overexpression was correlated with tumor size, poor differentiation, distant metastasis, and worse overall survival in nonsmall cell lung cancer. Therefore, Bmi-1 could be recommended as an efficient prognostic marker for nonsmall cell lung cancer.

Our data showed that Bmi1 is highly expressed in human non-small cell lung cancer (NSCLC) tissues and cell lines. Knockdown of Bmi1 significantly suppressed NSCLC cell proliferation and colony formation. Deguelin treatment attenuated the binding activity of Bmi1 to the Noxa promoter, thus resulting in Noxa transcription and apoptosis activation

Study unveiled a novel mitotic mechanism underlying BMI1-associated lethality using CRISPR-Cas9 derived knockouts of NUMA1 in both HAP1 cells and non-small lung cancer cell lines and highlighted a mechanism relying on mitotic arrest upon loss of BMI1 and a new genetic resistance mechanism. These observations add further knowledge to the complex and context-dependent involvement of BMI1 in cancer.