AA and AG genotypes of SDF-1 may have a role in the susceptibility of Iranian patients to lung cancer

CXCL12 expression may influence tumor progression by shaping the immune cell population infiltrating lung adenocarcinoma tumors.

bone marrow-derived-SDF-1alpha enhances the invasiveness of lung cancer cells by increasing MMP-9 expression through the CXCR4/ERK/NF-kappaB signal transduction pathway

Breast cancer metastasis suppressor 1 inhibits SDF-1alpha-induced migration of non-small cell lung cancer by decreasing CXCR4 expression.

CXCR4/SDF-1 pathway was critical for TLR9 agonist to enhance the metastasis of human lung cancer cells.

SDF-1alpha was strongly expressed in normal superior deep cervical lymph nodes, bone marrow, lung and liver but absent or very poor expression in inferior deep cervical lymph nodes, kidney and colon tissues in patients with nasopharyngeal carcinoma.

the VEGF-stromal cell-derived factor-1alpha/CXCL12 axis may have a role in pleural effusion of lung cancer

there is a significant association between the polymorphisms of CXCL12 and CXCR4, and the susceptibility to and prognosis of non-small cell lung cancer

Hugh serum SDF-1 is associated with pleural metastasis in non-small cell lung cancer.

Interaction between carcinoma-associated fibroblasts and tumor epithelial cells through the CXCL12/CXCR4 axis plays a role in non-small cell lung cancer tumor proliferation.

These findings suggest a possible role for the CXCL12/CXCR4 axis in the metastatic evolution of non-small-cell lung cancer

It induces lung cancer cell migration by polarized mtDNA redistribution.

CXCL12 and CXCR4 have a single ligand-single receptor relationship in mediating non-small cell lung cancer migration and metastasis, and in context of NSCLC that expresses CXCR4, the CXCR4-CXCL12 axis is not involved in angiogenesis of the primary tumor

ERbeta and CXCL12/CXCR4 expression in lung adenocarcinoma depends on sex and hormonal status, which may partly explain the sex and hormonal differences in lung cancer behavior.

genetic polymorphism is not associated with Non-Small Cell lung cancer in Tunisian patients

HIF-1alpha and reactive oxygen species mediate radiation-induced invasiveness through the SDF-1alpha/CXCR4 pathway in non-small cell lung carcinoma cells.

miR-101-CXCL12 pathway is partially responsible for cancer-associated fibroblast-mediated progression of lung cancer

study suggested that the SDF-1 rs1801157 polymorphism may serve as a risk factor for cancer development among Asians, especially an increased risk of urologic and lung cancers

Higher percentage of CXCR4-expressing lung metastatic cells compared to the corresponding primary tumors point to important functions of the CXCL12/CXCR4 axis in late steps of metastasis

Results show that CXCL12 is highly expressed in metastatic lymph node (MNL) of non-small cell lung neoplasm (NSCLC) and is associated with poor prognosis which suggest that CXCL12 may play a role in tumor progression of NSCLC.

EGFR Over-expression and mutations Leading to Biological Characteristics Changes of Human lung Adenocarcinoma Cells through CXCR4/CXCL12 Signaling pathway

Blocking SDF-1alpha activity with neutralizing antibodies abrogated bone marrow-derived neovascularization in lung cancer and retinopathy.