MCP-1 promotes lung cancer-induced osteoclast activity and thus bone resorptive lesions in vivo.

CCL2-expressing breast tumor cells engage CCR2(+) stromal cells of monocytic origin, including macrophages and preosteoclasts, to facilitate colonization in lung and bone

The MCP-1 -2518A/G polymorphism is associated with genetic susceptibility to non-small-cell lung cancer.

High monocyte chemoattractant protein-1 is associated with CD204-positive macrophages in lung squamous cell carcinoma.

Data show that TXA(2) mimetic, I-BOP, induced monocyte chemoattractant protein -1(MCP-1)/chemokine (C-C motif) ligand 2 (CCL2) expression at both mRNA and protein levels in lung adenocarcinoma A549 cells.

we found that Brachyury expression was inversely correlated with CCL2 and CCL4 expression in human lung tumors

A polymorphism in MCP-1 may be correlated with the development of non-small cell clung cancer (NSCLC) in the Han nationality of Northern China. However, the polymorphism in CCR-2 is not involved in NSCLC.

HUMSCs expressing ISZ-sTRAIL might be an efficient therapeutic approach against lung cancer and MCP-1/CCR2 axis is essential for the tumor tropism of HUMSCs

Our study suggested rs3760396 polymorphism of CCL2 is associated not only with prognosis of non-small cell lung cancer , but also with risk of lung cancer in a subtype-specific manner. Our results further supported previous evidence of the important role of CCL2 in lung cancer development

Using a combination of cytokine expression profiling and miRNAs algorithms, we identified VEGFA/CCL2 and FOXO3a as direct targets of miR-1, miR-206 and miR-31, respectively. Importantly, systemic delivery of anti-VEGFA/CCL2 or pre-miR-1, pre-miR-206 and anti-miR-31 significantly inhibited tumor angiogenesis, TAMs accumulation, tumor growth and lung metastasis.

the sensitivity and specificity of CEA, CA125, and ProGRP when used in combination with IL-6, IL-10, and MCP in lung cancer diagnosis, was examined.

IL-6 Mediates Macrophage Infiltration after Irradiation via Up-regulation of CCL2/CCL5 in Non-small Cell lung cancer

Given that IL-8, MIP-1beta, and MCP-1 are chemokines that play important roles in recruitment of immunocompetent cells for immune defense and tumor cell clearance, the observed lower levels of these markers with increasing PM2.5 exposure may provide insight into the mechanism by which DEE promotes lung cancer.

High CCL2 expression promotes breast cancer lung metastasis.

Our study revealed that CCL2 and CCL4 expression levels could serve as potential prognostic biomarkers and therapeutic targets for non small cell lung cancer patients

The MCP-1/chemokine (C-C motif) ligand 2 (CCL2) expression mediated by the autocrine loop of PDGF-BB enhanced recruitment of macrophages through CCL2-CCR2 axis, which could ultimately increase expression of metastatic genes in lung cancer cells, finally promoting invasive potential of cancer cells.