S100A8, S100A9 was up-regulated in the lung adenocarcinoma and end stage lung cancer tissue, the correlation of their higher expression in inflammatory lung tissues indicate the collaborative effect of inflammation on the progression of cancer.

Cell proteins associated with M1 and M2 macrophages are also expressed by other cell types in the tumour islets and stroma of patients with non-small cell lung cancer

These data demonstrate for the first time that S100A8/A9 expression in epithelial cancer cells causes enhanced infiltration of immune cells, especially neutrophils, and stimulates settlement of the cancer cells in the lung.

Extracellular S100A8/A9 induced by cancer-associated inflammation in the lung plays a pivotal role in lung cancer progression through anchorage-independent growth, migration and invasion. The S100A8/A9 signal use cell surface NPTNbeta which is highly elevated at mRNA and protein levels. Data indicate that S100A8/A9-NPTNbeta plays a pivotal role in lung cancer progression with dissemination through TRAF2-NFIA/NFIB signa...