activation of the c-Abl-PKCdelta-Rac1-p38 MAPK pathway in response to ionizing radiation signals conformational changes of Bak and Bax, resulting in mitochondrial activation-mediated apoptotic cell death in human non-small cell lung cancer cells

KAI1/CD82 decreased the metastatic phenotype of H1299 lung carcinoma cells by down-regulating Rac1 expression through the PI3K/Akt/mTOR pathway.

A positive prognostic value of immunohistologically determined Rac1 protein expression was found and Rac1 as a potential unfavorable prognosis biomarker in patients with early operable non-small cell lung cancer, is presented.

Rac1 is critical for tumor initiation and metastasis of human non-small cell lung adenocarcinoma

delta-catenin facilitated invasion of lung cancer cells by upregulating the mRNA and protein levels of Rac1

Non-small cell lung carcinoma cell motility, rac activation and metastatic dissemination are mediated by protein kinase C epsilon

Rac1b promotes K-ras-induced lung tumorigenesis.

RAC1 is an important downstream molecule of EGF-EGFR signaling involved in non-small-cell lung cancer cell migration.

Authors propose a model whereby vimentin promotes FAK stabilization through VAV2-mediated Rac1 activation. This model may explain why vimentin expressing metastatic lung cancer cells are more motile and invasive.

These findings indicate that RhoGDI2 repressed the activity of Rac1 and may be involved in the rearrangement of cytoskeleton in lung cancer cells.

We found that the polymorphisms of RAC1 rs836554, rs4720672, and rs12536544 were significantly associated with platinum-based chemotherapy toxicity in lung cancer patients

Rac1 and Rac1b were found to be significantly over expressed in serum of non small cell lung cancer patients compared to healthy controls

TIPE2 suppressed tumor invasiveness and angiogenesis in non-small cell lung cancer via inhibiting the activation of Rac1 and subsequently weakening its downstream effects, including F-actin polymerization and VEGF expression.

In this review, we summarize the recent advances in understanding the role of RAC1 in lung cancer and the underlying mechanisms and discuss its value in clinical therapy.

Low RAC1 expression promotes lung tumor metastasis.

we revisited the question of the relationship between Cav1 and Stat3-ptyr705 in non-transformed mouse fibroblasts and in human lung carcinoma cells, by examining their effect at different cell densities.Our results demonstrate that Cav1 downregulates cadherin-11, by a mechanism which requires the Cav1 scaffolding domain. This cadherin-11 downregulation, leads to a reduction in cRac1 and Stat3 activity levels.

Inhibitory effects of ceramide kinase on Rac1 activation, lamellipodium formation, cell migration, and metastasis of A549 lung cancer cells.

High expression of UBB, RAC1, and ITGB1 Predicts Worse Prognosis among Nonsmoking Patients with lung Adenocarcinoma through Bioinformatics Analysis.

Findings suggest the mechanisms by which tumor protein p53 (p53) operates to enhance vascular endothelium barrier function by mediating the opposing actions of Rac family small GTPase 1 (Rac1) and ras homolog family member A (RhoA) in pulmonary tissues.

HACE1 Prevents lung Carcinogenesis via Inhibition of RAC-Family GTPases.