None of the polymorphisms were found to play a key role in CYP1A1 inducibility or in the susceptibility to develop lung cancer

Study demonstrates that AHRR and F2RL3 methylation are strong predictors individually for lung cancer development.

Prospective study demonstrated that AHRR and F2RL3 methylation levels had inverse relationships with self-reported smoking status and accurately discriminated for both current- and former- smoking. Moreover, methylation markers distinguished former smokers from never-smokers with high accuracy and significantly associated with an increased risk of lung cancer.

AHRR (cg05575921) methylation is linked to smoking but does not provide independent prognostic information in lung cancer patients.

Results suggest that blood methylation at cg05575921 (AHRR) in non-smokers might indicate different exposures to PM2.5 and lung cancer which is a PM2.5-related disease.

AHRR methylation in heavy smokers: associations with smoking, lung cancer risk, and lung cancer mortality.