Links to all GeneRIF Items | 57144 |
PubMed (Gene Name) | Literature evidence |
|---|---|
| 23696025 (PAK5) | The PAK5-Egr1-MMP2 signaling pathway is a critical regulator of cell migration and invasion in lung cancer cells. |
| 23836671 (PAK5) | identified three kinases with gain-of-function mutations in lung cancer, namely FGFR4, MAP3K9, and PAK5. mutations in these kinases are activating toward the ERK pathway, and targeted depletion of the mutated kinases inhibits proliferation |
| 32721391 (PAK5) | PAK5 promotes the cell stemness ability by phosphorylating SOX2 in lung squamous cell carcinomas. |